Have questions? Visit https://www.reddit.com/r/SNPedia

HLA-DRA

From SNPedia
is agene
is mentioned by
Full namemajor histocompatibility complex, class II, DR alpha
EntrezGene3122
PheGenI3122
VariationViewer3122
ClinVarHLA-DRA
GeneCardsHLA-DRA
dbSNP3122
DiseasesHLA-DRA
SADR3122
HugeNav3122
wikipediaHLA-DRA
googleHLA-DRA
gopubmedHLA-DRA
EVSHLA-DRA
HEFalMpHLA-DRA
MyGene2HLA-DRA
23andMeHLA-DRA
UniProtP01903
EnsemblENSG00000204287
OMIM142860
# SNPs18
 Max MagnitudeChromosome positionSummary
rs104188532,445,032
rs144120198032,443,193
rs222713932,445,682
rs223980332,444,056
rs239518232,445,540
rs312987132,438,565
rs31298781.332,440,958
rs312988232,441,753
rs312988832,443,949
rs312988932,445,768
rs312989032,446,496
rs3135388232,445,274
rs3135391332,443,210
rs317792832,444,658
rs493535632,444,611
rs7192332,443,869
rs719432,444,703
rs926864532,440,750


This is the "major histocompatibility complex, class II, DR alpha" gene. It is also known as HLA-DRA1. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

HLA-DRA codes for the alpha subunit of the HLA DR loci, and is largely invariant. The variation in HLA-DR comes from the beta units, which is important for organ compatibility.

The DRA SNP A/G rs3135388 is a proxy for the DRB1*1501 allele, which is associated with MS. Concordance between the rs3135388 A allele and DRB1*1501 was found in 2730 of 2757 subjects by the International Multiple Sclerosis Genetics Consortium (2007).

For a full list of HLA gene SNPs, see the HLA page.