Have questions? Visit https://www.reddit.com/r/SNPedia

HLA-C

From SNPedia

is agene
is mentioned by
Full namemajor histocompatibility complex, class I, C
EntrezGene3107
PheGenI3107
VariationViewer3107
ClinVarHLA-C
GeneCardsHLA-C
dbSNP3107
DiseasesHLA-C
SADR3107
HugeNav3107
wikipediaHLA-C
googleHLA-C
gopubmedHLA-C
EVSHLA-C
HEFalMpHLA-C
MyGene2HLA-C
23andMeHLA-C
UniProtP10321
EnsemblENSG00000204525
OMIM142840
# SNPs5
 Max MagnitudeChromosome positionSummary
rs1319134331,273,332
rs182798226031,271,285
rs207448831,272,654
rs41550315031,269,487
rs41555616031,271,081


HLA-C(PSORS1), a gene/antigen member of the HLA family is associated with immune conditions. Over 300 alleles have been documented, with 44 common.

Variants are correlated with susceptibility to Psoriasis (HLA-Cw6 interaction with CDSN*TTC) and HIV (-35C-T, rs9264942).

HLA-C1 interaction with KIR2DL2 affects HSV-1 susceptibility.

HLA-C*05 may protect against MS.

Tag SNPs for HLA-C antitypes on the 1M Illumina chip[edit]

HLA SNP r2 HLA_FRQ SNP_FRQ
C*02:06 rs3093671 0.006 0.000 0.03
C*03:05 rs3093561 0.003 0.000 0.01
C*03:06 rs2517490 0.007 0.000 0.02
C*04:03 rs2269713 0.039 0.003 0.04
C*04:04 rs2074475 0.006 0.000 0.02
C*04:07 rs7774197 0.003 0.000 0.05
C*04:10 rs3819284 0.010 0.000 0.02
C*06:02 rs10484554 0.11
C*07:26 rs9296020 0.009 0.000 0.01
C*08:01 rs2524083 0.071 0.010 0.12
C*12:04 rs28732150 0.015 0.001 0.05
C*15:04 rs16899178 0.031 0.002 0.05
C*16:04 rs7747738 0.059 0.002 0.03
C*18:01 rs7759127 0.015 0.002 0.12