FTO

is a	gene
is	mentioned by
Full name	fat mass and obesity associated
EntrezGene	79068
PheGenI	79068
VariationViewer	79068
ClinVar	FTO
GeneCards	FTO
dbSNP	79068
Diseases	FTO
SADR	79068
HugeNav	79068
wikipedia	FTO
google	FTO
gopubmed	FTO
EVS	FTO
HEFalMp	FTO
MyGene2	FTO
23andMe	FTO
UniProt	Q9C0B1
Ensembl	ENSG00000140718
OMIM	610966
# SNPs	71

	Max Magnitude	Chromosome position	Summary
rs10163409	0	54,104,968
rs10852521	0	53,771,053
rs11075990	0	53,785,981
rs11075995	0	53,821,379
rs11075996	0	53,824,112
rs11075997	0	53,825,000
rs11076008	0	53,893,411
rs1108086	0	54,066,457
rs1121980	3	53,775,335
rs11642015	0	53,768,582
rs11642841	0	53,811,575
rs12149832	0	53,808,996
rs121918214	3	53,873,837
rs12595985	0	53,842,839
rs12596210	0	53,994,059
rs12597786	0	53,787,395
rs12927155	0	54,099,888
rs1420318	0	54,068,854
rs1421084	0	53,723,828
rs1421085	3.1	53,767,042	obesity risk
rs1477196	0	53,774,346
rs1558902	0	53,769,662
rs16945088	0	53,778,612
rs16953002	1.5	54,080,912
rs17219084	0	53,821,688
rs17817449	0	53,779,455
rs17817964	0	53,794,154
rs17818902	0	53,837,894
rs17820875	0	53,892,878
rs1861868	0	53,756,490
rs3751812	0	53,784,548
rs3826169	0	53,826,569
rs4784333	0	53,935,176
rs56137030	0	53,791,993
rs57103849	0	53,844,521
rs62033400	0	53,777,876
rs62048379	0	53,763,271
rs62048402	0	53,769,311
rs6499640	0	53,735,765
rs7185735	0	53,788,739
rs7190053	0	53,840,745
rs7193144	0	53,776,774
rs7195539	0	53,825,246
rs7202116	0	53,787,703
rs7204609	0	53,799,693
rs781028867	0	53,873,846
rs79206939	0	53,826,140
rs8043757	0	53,779,538
rs8044769	0	53,805,223
rs8047395	0	53,764,611
... further results

• 2015 research suggests rs1421085 may be the causal variant blog summary
• Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were 1.3 BMI units heavier than homozygotes for the common "A" allele. More than 30 additional SNPs in or near the FTO gene were also studied, but they are co-inherited most of the time with the rs9930506 SNP and therefore are unlikely to represent independent risk factors. These co-inherited SNPs include rs1421085, rs9937053, rs8043757, rs3751812, rs9923233, rs9932754, and rs9922619. [PMID 17658951]

• Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r²>0.97), and there are two primary haplotypes, C-G-A (42.0%; this is the haplotype representing obesity risk) and T-T-T (55.5%).

• Another report fingers rs1121980 within the FTO gene as having the strongest association to early onset obesity compared to several other SNPs all in the same linkage block. [PMID 18159244]

The earlier study also had conclusions with regard to another gene:

• Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele. They did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele. [PMID 17658951]

[1] the FTO SNP rs9939609 is associated with changes in BMI and obesity in children by the age of 7 which persists into the pre-pubertal period and beyond.

http://varigenome.blogspot.com/2013/06/fto-and-memory-connecting-dots.html

“Genetic associations with traits in 23andMe customers.” 23andMe White Paper.