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FGFR2

From SNPedia
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EntrezGene2263
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VariationViewer2263
ClinVarFGFR2
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# SNPs99
 Max MagnitudeChromosome positionSummary
rs10471000121,538,644
rs10510097121,568,362
rs10575190360121,520,092
rs10575190370121,520,084
rs10575190380121,520,076
rs10575190390121,520,049
rs10575190400121,519,995
rs10575190410121,517,465
rs10575190420121,517,396
rs10575190430121,517,391
rs10575190440121,517,390
rs10575190450121,498,522
rs10575190460121,498,521
rs10575190470121,488,055
rs10575197910121,518,810
rs10575197950121,488,002
rs10575197960121,496,546
rs10575197970121,496,705
rs10575197980121,498,528
rs10575197990121,498,556
rs10575198000121,498,562
rs10575198540121,488,063
rs10575199000121,515,259
rs10575199010121,498,525
rs10575200270121,488,005
rs10575200280121,515,283
rs10575200290121,488,003
rs10575200440121,498,597
rs10647964130121,488,052
rs10647964520121,515,262
rs10736303121,574,943
rs1078806121,579,461
rs11199993121,531,750
rs11200012121,572,901
rs11200014121,575,416
rs1219134740121,515,260
rs1219134750121,519,989
rs1219134760121,498,520
rs1219134770121,515,289
rs1219134780121,515,280
rs1219184870121,517,378
rs1219184880121,517,379
rs1219184890121,517,385
rs1219184900121,517,342
rs1219184910121,517,371
rs1219184920121,517,372
rs1219184930121,517,420
rs1219184940121,517,363
rs1219184950121,517,382
rs1219184960121,517,377
... further results


A relatively small increase in risk for sporadic postmenopausal ER+ breast cancer in European women has been reported to be highly significant for a haplotype of intron 2 of the FGFR2 gene.[PMID 17529973]

The primary SNP associated with this risk is rs1219648, however more recently, two neighboring SNPs (rs2981578 and rs7895676) from this same region have been postulated based on experimental evidence to be the causative factors. The minor alleles of these SNPs appear to increase FGFR2 expression and thereby to increase the risk for breast cancer.10.1371/journal.pbio.0060108


blog snps in COL11A1, LMNA, FGFR1, FGFR2, TRPS, BRAF, FLNA affect normal variation in facial features.