Have questions? Visit https://www.reddit.com/r/SNPedia

FGFR2

From SNPedia

is agene
is mentioned by
EntrezGene2263
PheGenI2263
VariationViewer2263
ClinVarFGFR2
GeneCardsFGFR2
dbSNP2263
DiseasesFGFR2
SADR2263
HugeNav2263
wikipediaFGFR2
googleFGFR2
gopubmedFGFR2
EVSFGFR2
HEFalMpFGFR2
MyGene2FGFR2
23andMeFGFR2
# SNPs98
 Max MagnitudeChromosome positionSummary
rs1047100121,538,644
rs10510097121,568,362
rs1057519036
rs1057519037
rs1057519038
rs1057519039
rs1057519040
rs1057519041
rs1057519042
rs1057519043
rs1057519044
rs1057519045
rs1057519046
rs1057519047
rs1057519791
rs1057519795
rs1057519796
rs1057519797
rs1057519798
rs1057519799
rs1057519800
rs1057519854
rs1057519900
rs1057519901
rs1057520027
rs1057520028
rs1057520029
rs1057520044
rs1064796413
rs1064796452
rs10736303121,574,943
rs1078806121,579,461
rs11199993121,531,750
rs11200012121,572,901
rs11200014121,575,416
rs121913474
rs121913475
rs121913476
rs1219134770121,515,289
rs1219134780121,515,280
rs1219184870121,517,378
rs1219184880121,517,379
rs1219184890121,517,385
rs1219184900121,517,342
rs1219184910121,517,371
rs1219184920121,517,372
rs1219184930121,517,420
rs1219184940121,517,363
rs1219184950121,517,382
rs1219184960121,517,377
... further results


A relatively small increase in risk for sporadic postmenopausal ER+ breast cancer in European women has been reported to be highly significant for a haplotype of intron 2 of the FGFR2 gene.[PMID 17529973]

The primary SNP associated with this risk is rs1219648, however more recently, two neighboring SNPs (rs2981578 and rs7895676) from this same region have been postulated based on experimental evidence to be the causative factors. The minor alleles of these SNPs appear to increase FGFR2 expression and thereby to increase the risk for breast cancer.10.1371/journal.pbio.0060108


blog snps in COL11A1, LMNA, FGFR1, FGFR2, TRPS, BRAF, FLNA affect normal variation in facial features.