CYP1A2
| is a | gene |
| is | mentioned by |
| Full name | cytochrome P450, family 1, subfamily A, polypeptide 2 |
| EntrezGene | 1544 |
| PheGenI | 1544 |
| VariationViewer | 1544 |
| ClinVar | CYP1A2 |
| GeneCards | CYP1A2 |
| dbSNP | 1544 |
| Diseases | CYP1A2 |
| SADR | 1544 |
| HugeNav | 1544 |
| CYPANC | cyp1a2 |
| wikipedia | CYP1A2 |
| CYP1A2 | |
| gopubmed | CYP1A2 |
| EVS | CYP1A2 |
| HEFalMp | CYP1A2 |
| MyGene2 | CYP1A2 |
| 23andMe | CYP1A2 |
| UniProt | P05177 |
| Ensembl | ENSG00000140505 |
| OMIM | 124060 |
| # SNPs | 19 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs11636419 | 0 | 74,755,259 | |
| rs12720461 | 2 | 74,749,010 | |
| rs17861162 | 0 | 74,756,412 | |
| rs2069525 | 0 | 74,748,031 | |
| rs2069526 | 0 | 74,749,000 | |
| rs2470890 | 0 | 74,755,085 | |
| rs2472304 | 0 | 74,751,897 | |
| rs28399424 | 2 | 74,754,828 | |
| rs35694136 | 0 | 74,747,272 | |
| rs3743484 | 0 | 74,752,059 | |
| rs55889066 | 0 | 74,753,234 | |
| rs56107638 | 0 | 74,753,271 | |
| rs56276455 | 0 | 74,751,854 | |
| rs72547511 | 0 | 74,749,863 | |
| rs72547513 | 2 | 74,750,296 | |
| rs72547515 | 0 | 74,752,211 | |
| rs72547516 | 0 | 74,752,237 | |
| rs72547517 | 0 | 74,754,904 | |
| rs762551 | 1.5 | 74,749,576 |
The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. One well known substrate of CYP1A2 is caffeine; individuals who carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers. The same amount of caffeine will therefore tend to have more stimulating effect on CYP1A2 slow metabolizers than on CYP1A2 fast metabolizers.
CYP1A2 can also be stimulated or inhibited by numerous medications and food-drug interactions. Fluoroquinolones, for example, are both metabolized by, and inhibit, the CYP1A2 enyzyme. This can slow the breakdown of caffeine, for example, leading to caffeine overstimulation. Conversely, smoking is a well-known activator of CYP1A2 (especially the CYP1A2*1F form), resulting in faster breakdown of drugs metabolized by CYP1A2 and the possibility of insufficient drug concentrations in the body to yield much therapeutic benefit.
Ciprofloxacin is metabolized by CYP1A2
Alleles of CYP1A2 include:
