Abacavir is the generic name of an antiviral drug used primarily to treat HIV+ and AIDS patients. It is prescribed under the trade name Ziagen as well as in the combination formulations Trizivir (abacavir, zidovudine and lamivudine) and Kivexa/Epzicom. More information about abacavir is available at Wikipedia.
The primary contraindication is a hypersensitive reaction that is likely to be genetic and can be severe. SNPs associated with the hypersensitive reaction are:
- rs2395029, acting as a proxy for the HLA-B*5701 allele