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ATR

From SNPedia
is agene
is mentioned by
Full nameATR serine/threonine kinase
EntrezGene545
PheGenI545
VariationViewer545
ClinVarATR
GeneCardsATR
dbSNP545
DiseasesATR
SADR545
HugeNav545
wikipediaATR
googleATR
gopubmedATR
EVSATR
HEFalMpATR
MyGene2ATR
23andMeATR
UniProtQ13535
EnsemblENSG00000175054
OMIM601215
# SNPs22
 Max MagnitudeChromosome positionSummary
rs130916370142,547,597
rs18029040142,449,489
rs1997315350142,549,478
rs22279280142,562,770
rs3879067970142,469,458
rs3879073270142,497,116
rs5877766900142,556,439
rs5877778510142,541,008
rs5877778520142,465,860
rs67824000142,576,526
rs68051180142,498,074
rs7497538990142,449,548
rs7540306240142,498,619
rs7552727690142,553,741
rs7595546020142,562,426
rs7648004680142,469,358
rs7692169930142,522,760
rs7708009880142,515,437
rs7708692930142,560,314
rs7779820830142,561,367
rs7812602350142,470,127
rs7970454030142,513,500

ATR, Serine/threonine-protein kinase, also known as rad3-related protein or FRAP-related protein, is a protein kinase involved in sensing DNA damage.

news "Women whose endometrial cancers have an ATR mutation have more than four times the risk of having their cancer return," study author Dr. Israel Zighelboim, a gynecologic oncologist, said in a news release from the university. "This and similar tumor biomarkers could potentially identify those patients most in danger of recurrence and guide the development of treatments aimed at these more aggressive tumors."

ATR mutations were found in about 5 percent of the 248 endometrioid endometrial tumor samples analyzed by the researchers. Women with ATR mutations were 4.29 times more likely to have the cancer recur after treatment and 3.88 times more likely to die.

The study appears online in the Journal of Clinical Oncology