Testing

From SNPedia

Consumer genotyping

23andMe uses a customized Illumina chip starting at $399, however you need to purchase the Complete Edition for $499 to be able to download your raw data.
deCODEme uses the Illumina Human 1M for $2000. Statistics about the overlaps between these platforms can be found in the FAQ
Navigenics uses the Affymetrix Genome-Wide Human SNP Array 6.0 for $2500. Raw data has been made available, but seems handled via email rather than a web interface.
Pathway Genomics offers various kits for Ancestry and Health, but seems not to release raw data
These two companies are believed to offer testing via the same platform as Navigenics,
- SeqWright uses the Affymetrix Genome-Wide Human SNP Array 6.0 for $998
- Gene Essence uses the Affymetrix Genome-Wide Human SNP Array 6.0 for $1195
Knome offers direct full genome sequencing for $95,000
The Personal Genome Project aims to recruit 100,000 volunteers and publish their genomes and medical information
Coriell Personalized Medicine Collaborative is free, but returns information on only ~6 snps which meet IRB approval
FamilyTreeDNA uses an Affymetrix chip (~500,000 SNPs) for autosomal ancestry testing at a $289 price point, including raw data download.

http://dnatestindex.com/providers/ provides a larger list

NEJM sets realistic expectations. Also note that current Affymetrix and Illumina microarray chips as used by 23andMe, deCODEme and others cover less than 50% of all likely genome variation at even 50% efficacy.[PMID 17726055]

Reminder: the heritability of medical conditions varies widely, from conditions that show little inherited genetic influence to those that are almost completely genetically determined (such as cystic fibrosis). A list summarizing some published heritability estimates for various medical conditions is available. We are also summarizing some average lifetime risks for many of these same conditions on the Lifetime Risk page.

Note: Anyone who wishes genetic counseling may find a counselor directly through several means, completely independent of the gene testing companies. In the U.S., the primary sources include the National Society of Genetic Counselors, asking your doctor, and checking with your healthcare insurer. If you are a qualified physician or genetic counselor interested in helping individuals interpret their genomic test results, please email us at info@snpedia.com as we intend to release a list of such individuals in the future.

At SNPedia, we have begun to collect pages about people's testing experiences. A particularly thoughtful article (among others) has been published by psychologist Steven Pinker (My Genome, My Self) based on his pondering his own DNA chip and (partial) DNA sequence data; it's well worth reading.

In the US, some people are wary of having genetic tests performed due to concerns over the possible use of genetic information by potential employers or insurance (health or life) companies in the absence of federal legislation banning genetic discrimination. Federal legislation known as GINA, the Genetic Information Nondiscrimination Act, was signed into law on May 21, 2008. Most states, but not all, have passed legislation providing either genetic privacy protection or some degree of protection against discrimination. The NIH/NHGRI maintains webpages about genetic discrimination primarily the federal level, and the National Conference of State Legislatures maintains a webportal surveying laws related to many aspects of genetics in different states.

For an interesting discussion (and possible solution) of the ways in which SNP/disease patents may threaten you or your physician from learning things about your health, see this article.

Testing

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