TCF7L2
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| EntrezGene | 6934 |
| PheGenI | 6934 |
| VariationViewer | 6934 |
| dbSNP | 6934 |
| SADR | 6934 |
| HugeNav | 6934 |
| wikipedia | TCF7L2 |
| TCF7L2 | |
| gopubmed | TCF7L2 |
| EVS | TCF7L2 |
| HEFalMp | TCF7L2 |
| 23andMe | TCF7L2 |
| UniProt | Q9NQB0 |
| Ensembl | ENSG00000148737 |
| OMIM | 602228 |
| EVS | TCF7L2 |
| # SNPs | 19 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| Rs10749127 | 114,849,353 | ||
| Rs10885406 | 114,777,724 | ||
| Rs11196205 | 114,807,047 | ||
| Rs11196218 | 114,840,494 | ||
| Rs12243326 | 114,788,815 | ||
| Rs12255372 | 3.5 | 114,808,902 | Associated with T2D, breast and prostate cancers. |
| Rs12573128 | 114,730,797 | ||
| Rs17747324 | 114,752,503 | ||
| Rs290481 | 114,923,825 | ||
| Rs290487 | 114,909,731 | ||
| Rs290489 | 114,907,055 | ||
| Rs3814570 | 114,708,510 | ||
| Rs4132670 | 114,767,771 | ||
| Rs4506565 | 114,756,041 | ||
| Rs6585194 | 114,717,471 | ||
| Rs7895340 | 114,801,525 | ||
| Rs7901695 | 114,754,088 | ||
| Rs7903146 | 3.5 | 114,758,349 | Associated with T2D. |
| Rs7924080 | 114,787,012 |
These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.
This has been confirmed by
- several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
- Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
- Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
- [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
- Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]
This news article summarizes how snps increase the risk
IHOP Information Hyperlinked Over Proteins.
[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes
