TCF7L2

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is agene
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Full nametranscription factor 7-like 2 (T-cell specific, HMG-box)
EntrezGene6934
PheGenI6934
VariationViewer6934
ClinVarTCF7L2
dbSNP6934
SADR6934
HugeNav6934
wikipediaTCF7L2
googleTCF7L2
gopubmedTCF7L2
EVSTCF7L2
HEFalMpTCF7L2
23andMeTCF7L2
UniProtQ9NQB0
EnsemblENSG00000148737
OMIM602228
EVSTCF7L2
# SNPs24
  Max Magnitude Chromosome position Summary
Rs10749127 114,849,353
Rs10885406 114,777,724
Rs11196174 114,734,096
Rs11196205 113,047,288
Rs11196218 114,840,494
Rs12243326 114,788,815
Rs12255372 3.5 113,049,143 Associated with T2D, breast and prostate cancers.
Rs12573128 114,730,797
Rs12772424 114,880,551
Rs17747324 114,752,503
Rs290481 114,923,825
Rs290487 114,909,731
Rs290489 114,907,055
Rs3814570 1.5 114,708,510
Rs4132670 114,767,771
Rs4506565 114,756,041
Rs6585194 114,717,471
Rs74157220 114,877,867
Rs7895340 114,801,525
Rs7901695 114,754,088
Rs7903146 3.5 112,998,590 Associated with T2D.
Rs7904519 114,773,927
Rs7917983 114,732,882
Rs7924080 114,787,012

These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.

This has been confirmed by

  • several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
  • Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
  • Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
  • [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
  • Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]


This news article summarizes how snps increase the risk



IHOP Information Hyperlinked Over Proteins.


PolyDoms Snap


[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes