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TCF7L2

From SNPedia
Revision as of 04:34, 3 December 2010 by Jlick (Talk | contribs)

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is agene
is mentioned by
Full nametranscription factor 7-like 2 (T-cell specific, HMG-box)
EntrezGene6934
PheGenI6934
VariationViewer6934
ClinVarTCF7L2
dbSNP6934
SADR6934
HugeNav6934
wikipediaTCF7L2
googleTCF7L2
gopubmedTCF7L2
EVSTCF7L2
HEFalMpTCF7L2
23andMeTCF7L2
UniProtQ9NQB0
EnsemblENSG00000148737
OMIM602228
# SNPs28
 Max MagnitudeChromosome positionSummary
Rs10749127113,089,594
Rs10885406113,017,965
Rs11196172112,967,084
Rs11196174112,974,337
Rs11196205113,047,288
Rs11196218113,080,735
Rs11196224113,095,638
Rs12243326113,029,056
Rs122553723.5113,049,143Associated with T2D, breast and prostate cancers.
Rs12573128112,971,038
Rs12772424113,120,792
Rs17747324112,992,744
Rs290475113,114,260
Rs290481113,164,066
Rs290487113,149,972
Rs290489113,147,296
Rs38145701.5112,948,751
Rs4132670113,008,012
Rs45065652112,996,282
Rs6585194112,957,712
Rs7094463112,952,224
Rs74157220113,118,108
Rs7895340113,041,766
Rs7901695112,994,329
Rs79031463.5112,998,590Associated with T2D.
Rs7904519113,014,168
Rs7917983112,973,123
Rs7924080113,027,253

These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.

This has been confirmed by

  • several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
  • Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
  • Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
  • [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
  • Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]


This news article summarizes how snps increase the risk



IHOP Information Hyperlinked Over Proteins.


PolyDoms Snap


[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes