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PMID: 16563182 This SNP in can have implications for prognosis in breast cancer.
It is located 313 base pairs upstream of the 5'-untranslated region of SIPA1 and is considered to be within the promoter region of the gene. SIPA1 germline polymorphisms are associated with aggressive disease behavior(lymph node metastasis) in the cohort examined
[PMID 19906411] Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer
[PMID 19089925] Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis.
[PMID 19264455] Linkage analysis of schizophrenia in African-American families.
[PMID 19765277] Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility.
[PMID 23661532] Sipa1 promoter polymorphism predicts risk and metastasis of lung cancer in Chinese