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{{ population diversity | geno1=(A;A) | geno2=(A;C) | geno3=(C;C) | CEU | 0.0 | 26.1 | 73.9 | HCB | 6.7 | 46.7 | 46.7 | JPT | 2.2 | 51.1 | 46.7 | YRI | 0.7 | 28.7 | 70.6 | ASW | 0.0 | 15.8 | 84.2 | CHB | 6.7 | 46.7 | 46.7 | CHD | 10.3 | 42.1 | 47.7 | GIH | 1.0 | 33.3 | 65.7 | LWK | 0.9 | 31.1 | 67.9 | MEX | 1.8 | 7.3 | 90.9 | MKK | 0.0 | 14.6 | 85.4 | TSI | 0.0 | 12.1 | 87.9 | HapMapRevision=28 }} [[rs9300039]], a SNP on chromosome 11 that is unusual is being over 1,000,000 base-pairs away from the nearest known gene, has been identified as a risk factor for [[type-2 diabetes]] in a study of over 2,000 Caucasian patients. The odds ratio for the risk allele [[rs9300039]](C) was 1.48, (CI: 1.28-1.71, p=5.7x10e-8). {{PMID|17463248}} This SNP is also mentioned in a related [http://suicyte.wordpress.com/2007/05/28/soul-searching-ii/ blog] series. Called into question by table 1 of {{doi|10.1371/journal.pbio.1000294}} {{GWAS Summary |SNP=rs9300039 |PubMedID=17463248 |Condition=Type 2 diabetes |Gene=Intergenic |Risk Allele=C |pValue=4.00E-007 |OR=1.25 |95CI=1.15-1.37 }} {{PharmGKB |RSID=rs9300039 |Name_s= |Gene_s=- |Feature= |Evidence=PubMed ID:17463248; Web Resource:http://www.genome.gov/gwastudies/ |Annotation=GWAS Results: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants (Initial Sample Size: 1,161 cases, 1,174 controls; Replication Sample Size: 1,215 cases, 1,258 controls; Risk Allele: rs9300039-C). |Drugs= |Drug Classes= |Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2 |Curation Level=Non-Curated |PharmGKB Accession ID=PA162356613 }} {{PharmGKB |RSID=rs9300039 |Name_s= |Gene_s=- |Feature= |Evidence=PubMed ID:17463248 |Annotation=In a large Finnish case-control GWAS, rs9300039 was found to be associated with susceptibility to Type 2 Diabetes. |Drugs= |Drug Classes= |Diseases=Diabetes Mellitus, Type 2 |Curation Level=Curated |PharmGKB Accession ID=PA162191357 }} {{PMID|17786212}} Heterogeneity in meta-analyses of genome-wide association investigations. {{PMID|17827400}} Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. {{PMID|18162508}} Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. {{PMID|18224312}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. {{PMID|18443202}} Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. {{PMID|18633108}} Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. {{PMID|18689899}} Exchangeable models of complex inherited diseases. {{PMID|19008344}} Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. {{PMID|20554072}} Gestational diabetes mellitus screening based on the gene chip technique. {{PMID|20823317}} is-rSNP: a novel technique for in silico regulatory SNP detection. {{PMID|21278902}} Genetic risk profiling for prediction of type 2 diabetes. {{PMID|21283728}} Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease. {{GET Evidence |impact=pathogenic |qualified_impact=Insufficiently evaluated pathogenic |inheritance=unknown |quality_scores=Array |dbsnp_id=rs9300039 |overall_frequency_n=10 |overall_frequency_d=128 |overall_frequency=0.078125 |n_genomes=9 |n_genomes_annotated=0 |n_haplomes=9 |n_articles=1 |n_articles_annotated=0 |in_gwas=Y |in_pharmgkb=Y |autoscore=2 |webscore=N }} {{ on chip | 23andMe v1 }} {{ on chip | Illumina Human 1M }} {{on chip | 23andMe v1}} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}} {{on chip | HumanOmni1Quad}} {{on chip | Illumina Human 1M}}
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