Rs807701

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Orientationminus
is asnp
is mentioned by
dbSNPrs807701
PheGenIrs807701
nextbiors807701
hapmaprs807701
1000 genomesrs807701
hgdprs807701
ensemblrs807701
gopubmedrs807701
geneviewrs807701
scholarrs807701
googlers807701
pharmgkbrs807701
gwascentralrs807701
openSNPrs807701
23andMers807701
23andMe allrs807701
SNP Nexus

SNPshotrs807701
SNPdbers807701
MSV3drs807701
GeneDCDC2
Chromosome6
Orientationminus
GMAF0.4178
Position24273563
ReferenceGRCh38 38.1/141
Max Magnitude2.1
Geno Mag Summary
(C;C) 2.1 2-5x increased dyslexia risk
(C;T) 1.5 Slightly increased dyslexia risk
(T;T) 1 Normal dyslexia risk
? (C;C) (C;T) (T;T) 28
Rs807701, a SNP in the DCDC2 gene, is in a region that crops up in several independent studies as likely to associated with dyslexia. The risk allele in the Caucasian populations studied is (C).

One study reports that the odds ratio for rs807701 genotypes increases if calculated from subsets of more severely dyslexic individuals as compared to more heterogenous, larger groups of dyslexic individuals. The genotype relative risk (GRR) for rs807701(C;C) increased from 1.88 (95% CI 0.89-3.97; P=.058) for the larger group up to 5.04 (95% CI 1.35-18.88; P=.002) for the most severely affected group. [PMID 16385449OA-icon.png]

Combined with another SNP marker in the DCDC2 gene, rs793862, the (haplotype) GRR also increased for the homozygous haplotype rs793862(A)-rs807701(C), from 4.11 (95% CI 2.77-6.08; P<.0001) for the larger group, up to 11.13 (95% CI 6.32-19.60; P<.0001) for the most severely affected group. [PMID 16385449OA-icon.png]


[PMID 19238550] The role of gene DCDC2 in German dyslexics.


[PMID 23229871] Meta-analysis of the association between DCDC2 polymorphisms and risk of dyslexia.