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Rs793862

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Orientationplus
is asnp
is mentioned by
dbSNPrs793862
PheGenIrs793862
hapmaprs793862
1000 genomesrs793862
hgdprs793862
ensemblrs793862
gopubmedrs793862
geneviewrs793862
scholarrs793862
googlers793862
pharmgkbrs793862
gwascentralrs793862
openSNPrs793862
23andMers793862
23andMe allrs793862
SNP Nexus

SNPshotrs793862
SNPdbers793862
MSV3drs793862
GeneDCDC2
Chromosome6
Orientationplus
GMAF0.4105
Position24206972
ReferenceGRCh38 38.1/141
Max Magnitude2
Geno Mag Summary
(A;A) 2 3-5x dyslexia risk
(A;G) increased dyslexia risk
(G;G) 0 common
Rs793862, a SNP in the DCDC2 gene, is in a region that crops up in several independent studies as likely to associated with dyslexia. The risk allele in the Caucasian populations studied is (A).

One study reports that the odds ratio for rs793862 genotypes increases if calculated from subsets of more severely dyslexic individuals as compared to more heterogenous, larger groups of dyslexic individuals. The genotype relative risk (GRR) for rs793862(A;A) increased from 3.15 (95% CI 1.30-7.66; P=.011) for the larger group up to 5.40 (95% CI 1.27-23.01; P=.002) for the most severely affected group. [PMID 16385449OA-icon.png]

Combined with another SNP marker in the DCDC2 gene, rs807701, the (haplotype) GRR also increased for the homozygous haplotype A-C, from 4.11 (95% CI 2.77-6.08; P<.0001) for the larger group, up to 11.13 (95% CI 6.32-19.60; P<.0001) for the most severely affected group. [PMID 16385449OA-icon.png]

This SNP was also reported to be significantly associated in a linkage study of dyslexic individuals. [PMID 15138886]


[PMID 15717286OA-icon.png] Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.


[PMID 19238550] The role of gene DCDC2 in German dyslexics.


[PMID 21881542OA-icon.png] DCDC2 genetic variants and susceptibility to developmental dyslexia.


[PMID 25012462] The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems