Rs7341475

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Orientationplus
is asnp
is mentioned by
dbSNPrs7341475
PheGenIrs7341475
nextbiors7341475
hapmaprs7341475
1000 genomesrs7341475
hgdprs7341475
ensemblrs7341475
gopubmedrs7341475
geneviewrs7341475
scholarrs7341475
googlers7341475
pharmgkbrs7341475
gwascentralrs7341475
openSNPrs7341475
23andMers7341475
23andMe allrs7341475
SNP Nexus

SNPshotrs7341475
SNPdbers7341475
MSV3drs7341475
GeneRELN
Chromosome7
Orientationplus
GMAF0.157
Position103404815
ReferenceGRCh37 37.1/131
Max Magnitude1.5
Geno Mag Summary
(A;A) 0 normal
(A;G) 0 normal
(G;G) 1.5 1.58x increased schizophrenia risk for women
? (A;A) (A;G) (G;G) 28

A total of 2,274 cases of schizophrenia were studied, resulting in an association between rs7341475, exclusively in women. Based on all populations the estimated relative risk for women carrying the common (G;G) genotype is 1.58 (p = 8.8 x 10(-7).[PMID 18282107OA-icon.png]

This finding was replicated in a large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female), with confirmation that it applies to both schizophrenia and schizoaffective disorder.[PMID 20431428OA-icon.png]



[PMID 21603580OA-icon.png] The genetic variation of RELN expression in schizophrenia and bipolar disorder


[PMID 22006801] [Association of RELN SNP rs7341475 with schizophrenia in the Chinese population]


[PMID 19002143OA-icon.png] Sex-specific genetic architecture of human disease.


[PMID 19197363OA-icon.png] A genome-wide investigation of SNPs and CNVs in schizophrenia.


[PMID 19911060OA-icon.png] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.


[PMID 20434133OA-icon.png] No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression.


[PMID 20468075] Further investigation of the association between rs7341475 and rs17746501 and schizophrenia.


[PMID 20485477OA-icon.png] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?


[PMID 21195391] Association of reelin (RELN) single nucleotide polymorphism rs7341475 with prepulse inhibition in the Jewish Israeli population.


[PMID 21745129] Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population.


GET Evidence
rs7341475
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.148438
summary susceptibility to bipolar and schizophrenia possibly specific to Ashkenazi Jews.