Rs7183877

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Orientationplus
Geno Mag Summary
(A;A) usually brown eye color
(A;C) usually brown eye color
(C;C) blue eye color if part of blue eye color haplotype
ReferenceGRCh38 38.1/141
Chromosome15
Position28120587
GeneHERC2
is asnp
is mentioned by
dbSNPrs7183877
Exacrs7183877
PheGenIrs7183877
nextbiors7183877
hapmaprs7183877
1000 genomesrs7183877
hgdprs7183877
ensemblrs7183877
gopubmedrs7183877
geneviewrs7183877
scholarrs7183877
googlers7183877
pharmgkbrs7183877
gwascentralrs7183877
openSNPrs7183877
23andMers7183877
23andMe allrs7183877
SNP Nexus

SNPshotrs7183877
SNPdbers7183877
MSV3drs7183877
GMAF0.1703
Max Magnitude
? (A;A) (A;C) (C;C) 28
rs7183877 is part of a haplotype spanning 166kB on chromosome 15, defined by 13 SNPs listed below, found in 97% of all Caucasians with blue eyes. In this haplotype, variations in rs1129038 and rs12913832 are relatively common in Caucasians though rare among other ethnic groups.[PMID 18172690]

The "h-1" haplotype found in homozygous state in 97% of individuals with blue eye color is composed as follows [PMID 18172690]:

rs4778241(C)
rs1129038(A)
rs12593929(A)
rs12913832(G)
rs7183877(C)
rs3935591(G)
rs7170852(A)
rs2238289(T)
rs3940272(C)
rs8028689(T)
rs2240203(A)
rs11631797(G)
rs916977(G)

Neighborrs12913832
Distance115
[PMID 18252221OA-icon.png] Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.


[PMID 18483556OA-icon.png] A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.


[PMID 20585627OA-icon.png] Web-based, participant-driven studies yield novel genetic associations for common traits.