Rs6314
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6314 |
| PheGenI | rs6314 |
| nextbio | rs6314 |
| hapmap | rs6314 |
| 1000 genomes | rs6314 |
| hgdp | rs6314 |
| ensembl | rs6314 |
| gopubmed | rs6314 |
| geneview | rs6314 |
| scholar | rs6314 |
| rs6314 | |
| pharmgkb | rs6314 |
| gwascentral | rs6314 |
| openSNP | rs6314 |
| 23andMe | rs6314 |
| 23andMe all | rs6314 |
| SNP Nexus | |
| SNPshot | rs6314 |
| SNPdbe | rs6314 |
| MSV3d | rs6314 |
| Gene | HTR2A |
| Chromosome | 13 |
| Orientation | minus |
| GMAF | 0.0687 |
| Position | 47409034 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 0 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | higher risk for RA |
| (C;T) | higher risk for RA; better response to paroxetine as treatment for depression | |
| (T;T) | 0 | average |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
Based on a study of 166 Caucasian patients being treated for depression with paroxetine, rs6314 heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01).10.1038/sj.tpj.6500491
- rs6314 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6314(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.
[PMID 19584773] Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort
- "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."
[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes
Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.[PMID 18712714]
[PMID 16380908] Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
[PMID 16642433] Polymorphism in maternal LRP8 gene is associated with fetal growth.
[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 18611292] The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans.
[PMID 19077664] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
[PMID 19359258] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 22615781] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
| GET Evidence | |
|---|---|
| HTR2A-H452Y | |
| aa_change | His452Tyr |
| aa_change_short | H452Y |
| impact | pharmacogenetic |
| qualified_impact | Insufficiently evaluated pharmacogenetic |
| overall_frequency | 0.109221 |
| summary | |
[PMID 23544600] Two Functional Serotonin Polymorphisms Moderate the Effect of Food Reinforcement on BMI
