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Geno Mag Summary
(C;C) 0 higher risk for RA
(C;T) higher risk for RA; better response to paroxetine as treatment for depression
(T;T) 0 average
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs6314
23andMe allrs6314
SNP Nexus

Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs6314, also known as C1354T or His452Tyr/H452Y, is a SNP in the serotonin 2A receptor HTR2A gene.

Based on a study of 166 Caucasian patients being treated for depression with paroxetine, rs6314 heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01).10.1038/sj.tpj.6500491

Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.

[PMID 19584773] Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort

"Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."

[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes

Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.[PMID 18712714OA-icon.png]

[PMID 16380908OA-icon.png] Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.

[PMID 16642433OA-icon.png] Polymorphism in maternal LRP8 gene is associated with fetal growth.

[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

[PMID 18611292] The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans.

[PMID 19077664OA-icon.png] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

[PMID 19359258OA-icon.png] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 22615781OA-icon.png] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study

GET Evidence
aa_change His452Tyr
aa_change_short H452Y
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.109221

[PMID 23544600] Two Functional Serotonin Polymorphisms Moderate the Effect of Food Reinforcement on BMI

[PMID 23842608] Converging Evidence for the Association of Functional Genetic Variation in the Serotonin Receptor 2a Gene With Prefrontal Function and Olanzapine Treatment

[PMID 23808549] Candidate gene associations with withdrawn behavior.

[PMID 24968012] Serotonin 2A Receptor Gene (HTR2A) Regulatory Variants: Possible Association with Severity of Depression Symptoms in Children with Autism Spectrum Disorder