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rs6314, also known as C1354T or His452Tyr/H452Y, is a SNP in the serotonin 2A receptor HTR2A gene.
Based on a study of 166 Caucasian patients being treated for depression with paroxetine, rs6314 heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01).10.1038/sj.tpj.6500491
- rs6314 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6314(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.
[PMID 19584773] Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort
- "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs rs3125, rs6314, rs1923886, rs2224721 and rs2770296) is protective against bipolar disorder (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."
[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes
[PMID 16380908] Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
[PMID 16642433] Polymorphism in maternal LRP8 gene is associated with fetal growth.
[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 18611292] The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans.
[PMID 19077664] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
[PMID 19359258] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 22615781] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23544600] Two Functional Serotonin Polymorphisms Moderate the Effect of Food Reinforcement on BMI
[PMID 23842608] Converging Evidence for the Association of Functional Genetic Variation in the Serotonin Receptor 2a Gene With Prefrontal Function and Olanzapine Treatment
[PMID 23808549] Candidate gene associations with withdrawn behavior.
[PMID 24968012] Serotonin 2A Receptor Gene (HTR2A) Regulatory Variants: Possible Association with Severity of Depression Symptoms in Children with Autism Spectrum Disorder