rs6313, also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6313(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.
[PMID 19387614] HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients
[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population
[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes
[PMID 20431430] The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness
[PMID 20827275] Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects
[PMID 21089166] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis
[PMID 21089121] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis
[PMID 21969281] Influence of birth weight on internalizing traits modulated by serotonergic genes
[PMID 15882913] The KPNA3 gene may be a susceptibility candidate for schizophrenia.
[PMID 16272956] CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents.
[PMID 16642436] Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.
[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.
[PMID 17521439] Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.
[PMID 17590256] 5-HT2A SNPs and the Temperament and Character Inventory.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17964050] Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.
[PMID 18191318] Association study between obsessive-compulsive disorder and serotonergic candidate genes.
[PMID 18196244] Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
[PMID 18712714] Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.
[PMID 18797395] Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts.
[PMID 18801406] Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.
[PMID 19184136] Examination of association of genes in the serotonin system to autism.
[PMID 19197363] A genome-wide investigation of SNPs and CNVs in schizophrenia.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19545856] Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.
[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 20403506] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21136126] Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
[PMID 21162693] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21320838] Variations in 5-HT2A influence spatial cognitive abilities and working memory.
[PMID 21621273] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.
[PMID 21930285] The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.
[PMID 22545912] Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population.