rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met.
[PMID 20042999] Met/A allele associated with introversion
On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]
[PMID 18600033] Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour
[PMID 19209189] In 2 studies of British women, rs6265(A;A) women had a lower body mass index than rs6265(G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.
[PMID 19388013] BDNF, relative preference, and reward circuitry responses to emotional communication
|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||4.58 [3.07-6.09] % SD|
[PMID 19461660] No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
[PMID 19530966] Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis
[PMID 20943059] Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms
[PMID 15940292] A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
[PMID 18286632] Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder
[PMID 19699537] Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent
[PMID 19925205] Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging
[PMID 20033742] Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population
[PMID 19895626] The effect of BDNF gene variants on asthma in German children
[PMID 20087404] Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study
[PMID 20147969] Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension
[PMID 20418890] Genome-wide meta-analyses identify multiple loci associated with smoking behavior
[PMID 20682308] The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder
[PMID 20456319] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
[PMID 20702703] The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks
[PMID 20959432] BDNF and CGRP interaction: Implications in migraine susceptibility
[PMID 20966902] Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women
[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder
[PMID 20843981] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
[PMID 21300947] The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease
[PMID 21723144] Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore
[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
[PMID 21527513] Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity
[PMID 21889574] Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder
[PMID 21980924] BDNF Val66Met and Cognition: All, None, or Some? A Meta-Analysis of the Genetic Association
[PMID 22033217] Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women
[PMID 22085476] Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene
[PMID 22127997] No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese
[PMID 22173577] Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans
[PMID 22188054] Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury
[PMID 22194877] Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding
[PMID 21641949] Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population
[PMID 21880305] The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response
[PMID 22548711] Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population
[PMID 22719849] Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults
[PMID 22766130] BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis
|Disease||Memory impairment Obsessive-compulsive disorder Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder Parkinson disease|
|CLNDBN||Memory impairment, susceptibility to Obsessive-compulsive disorder, protection against Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder, susceptibility to Parkinson disease, age at onset, susceptibility to|
|CLNSRC||OMIM Allelic Variant|
|CLNACC||RCV000019267.1, RCV000019268.1, RCV000019269.1, RCV000019270.1, RCV000019271.1, RCV000019272.1,|
[PMID 12836135] Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.
[PMID 15457498] Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.
[PMID 16005437] Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.
[PMID 16497333] No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults.
[PMID 16631352] No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population.
[PMID 16741941] Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.
[PMID 16962786] Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
[PMID 17096834] No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.
[PMID 17135278] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
[PMID 17196936] Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis.
[PMID 17212826] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
[PMID 17219016] No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.
[PMID 17417060] Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
[PMID 17483451] Gene-gene interaction associated with neural reward sensitivity.
[PMID 17503330] A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
[PMID 17602759] Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis.
[PMID 17632285] The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.
[PMID 17656372] Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.
[PMID 17657167] Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.
[PMID 17894414] BDNF Val66Met variant and age of onset in schizophrenia.
[PMID 17918236] Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder.
[PMID 18205169] Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.
[PMID 18478177] Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine.
[PMID 18534558] Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
[PMID 18565990] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
[PMID 18698231] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
[PMID 18704161] Genetic variation in an individual human exome.
[PMID 18776599] Susceptibility genes for gentamicin-induced vestibular dysfunction.
[PMID 18813964] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
[PMID 18830724] Assessment of Alzheimer's disease case-control associations using family-based methods.
[PMID 18852698] Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.
[PMID 18957941] Genome-wide association scan for five major dimensions of personality.
[PMID 19018231] Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.
[PMID 19018715] Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.
[PMID 19236730] Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response.
[PMID 19258022] Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
[PMID 19295238] Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
[PMID 19330778] Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population.
[PMID 19336781] Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.
[PMID 19359258] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
[PMID 19412541] Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.
[PMID 19424874] Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 19582215] Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray.
[PMID 19582565] Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
[PMID 19721723] Brain-derived neurotrophic factor: role in depression and suicide.
[PMID 19721846] Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants.
[PMID 19844571] Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
[PMID 19940176] Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
[PMID 19953912] [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].
[PMID 20004415] Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 20014955] Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression.
[PMID 20016225] Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients.
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20172611] Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder.
[PMID 20191112] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
[PMID 20400928] Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.
[PMID 20426150] Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture.
[PMID 20478698] Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study.
[PMID 20482942] Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.
[PMID 20493546] BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.
[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21037213] Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
[PMID 21049304] Influence of candidate genes on attention problems in children: a longitudinal study.
[PMID 21097659] Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects.
[PMID 21103954] Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population.
[PMID 21167606] The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21215389] The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.
[PMID 21305693] Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction.
[PMID 21458533] Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence.
[PMID 21491204] Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF.
[PMID 21509595] Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
[PMID 21577214] BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.
[PMID 21640793] Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients.
[PMID 21695421] Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?
[PMID 21745335] 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.
[PMID 21875455] The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.
[PMID 21898033] Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.
[PMID 21931317] BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.
[PMID 21956459] Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment.
[PMID 21996278] Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.
[PMID 22008662] The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior.
[PMID 22094229] Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.
[PMID 22179955] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
[PMID 22585743] Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.
[PMID 22609366] Neurotrophic Tyrosine Kinase Polymorphism Impacts White Matter Connections in Patients with Major Depressive Disorder.
[PMID 22610920] The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
[PMID 22642961] The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.
[PMID 22965830] No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression
[PMID 22615781] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23170235] BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humans
[PMID 23269345] BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects
[PMID 23341118] Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume
[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia
[PMID 23482723] Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
[PMID 23487199] BDNF val66met Polymorphism Is Associated With Age at Onset and Intensity of Symptoms of Paranoid Schizophrenia in a Polish Population
[PMID 23628854] FTO predicts weight regain in the Look AHEAD clinical trial
[PMID 23712400] SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans
[PMID 23923080] Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia
[PMID 23424664] Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
[PMID 23999029] Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder
[PMID 23433505] Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia
[PMID 24198753] Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking
[PMID 24269186] An obesity genetic risk score is associated with metabolic syndrome in Chinese children
[PMID 24399714] BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample
[PMID 24567226] Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols
[PMID 23408508] Obesity-susceptibility loci and the tails of the pediatric BMI distribution
[PMID 22813992] Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis.
[PMID 22844024] Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.
[PMID 22846907] Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.
[PMID 22989210] Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.
[PMID 23023098] Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes.
[PMID 23062292] The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems.
[PMID 23137999] The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.
[PMID 23184535] No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.
[PMID 23303061] Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment.
[PMID 23461616] Association between brain-derived neurothropic factor variants and asthma in Chinese Han children.
[PMID 23643991] Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults.
[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
[PMID 23832605] Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.
[PMID 24863266] Val66Met polymorphism in the BDNF gene in children with bronchial asthma
[PMID 24993285] BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia
[PMID 25044977] BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields
[PMID 25052186] Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris