| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
less likely to gain weight if taking olanzapine
|
| (A;G)
|
|
less likely to gain weight if taking olanzapine
|
| (G;G)
|
|
normal
|
rs5092 is a SNP in the apolipoprotein A4
APOA4 gene.
In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs5092(G) allele were less likely to gain significant weight compared to rs5092(A;A) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs4765623 and rs7412, were also significantly associated with weight profiles in these patients.[PMID 17199131]
[PMID 19592705] Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
