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[[rs5092]] is a SNP in the apolipoprotein A4 [[APOA4]] gene. In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic [[olanzapine]], carriers of a [[rs5092]](G) allele were less likely to gain significant weight compared to [[rs5092]](A;A) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, [[rs4765623]] and [[rs7412]], were also significantly associated with weight profiles in these patients.{{PMID|17199131}} {{PMID Auto |PMID=19592705 |Title=Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men }} {{PMID Auto |PMID=18254975 |Title=Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat. }} {{PMID Auto |PMID=19057464 |Title=Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. }} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}}
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