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Rs4765623

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Orientationplus
is asnp
is mentioned by
dbSNPrs4765623
PheGenIrs4765623
nextbiors4765623
hapmaprs4765623
1000 genomesrs4765623
hgdprs4765623
ensemblrs4765623
gopubmedrs4765623
geneviewrs4765623
scholarrs4765623
googlers4765623
pharmgkbrs4765623
gwascentralrs4765623
openSNPrs4765623
23andMers4765623
23andMe allrs4765623
SNP Nexus

SNPshotrs4765623
SNPdbers4765623
MSV3drs4765623
GeneSCARB1
Chromosome12
Orientationplus
Position125320850
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(C;C) more likely to gain weight if taking olanzapine
(C;T) more likely to gain weight if taking olanzapine
(T;T) 0 normal
? (C;C) (C;T) (T;T) 28
rs4765623 is a SNP in the scavenger receptor class B, member 1 SCARB1 gene.

In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs4765623(C) allele were more likely to gain significant weight compared to rs4765623(T;T) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs5092 and rs7412, were also significantly associated with weight profiles in these patients.[PMID 17199131]

GWAS snp
PMID [PMID 21131975]
Trait
Title Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
Risk Allele
P-val 3E-8
Odds Ratio 1.1500 [1.09-1.20]


[PMID 22131124] Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population