Rs4765623

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs4765623
PheGenI	rs4765623
nextbio	rs4765623
hapmap	rs4765623
1000 genomes	rs4765623
hgdp	rs4765623
ensembl	rs4765623
gopubmed	rs4765623
geneview	rs4765623
scholar	rs4765623
google	rs4765623
pharmgkb	rs4765623
gwascentral	rs4765623
openSNP	rs4765623
23andMe	rs4765623
23andMe all	rs4765623
SNP Nexus
SNPshot	rs4765623
SNPdbe	rs4765623
MSV3d	rs4765623

Gene

SCARB1

Chromosome

12

Orientation

plus

Position

125320850

Reference

GRCh37 37.1/131

Max Magnitude

0

Geno	Mag	Summary
(C;C)		more likely to gain weight if taking olanzapine
(C;T)		more likely to gain weight if taking olanzapine
(T;T)	0	normal

?	(C;C) (C;T) (T;T)	28

rs4765623 is a SNP in the scavenger receptor class B, member 1 SCARB1 gene.

In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs4765623(C) allele were more likely to gain significant weight compared to rs4765623(T;T) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs5092 and rs7412, were also significantly associated with weight profiles in these patients.[PMID 17199131]

GWAS snp
PMID	[PMID 21131975]
Trait
Title	Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
Risk Allele
P-val	3E-8
Odds Ratio	1.1500 [1.09-1.20]

[PMID 22131124] Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population