rs4570625, also known as G-703T, is a SNP in the tryptophan hydroxylase 2 TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:
- [PMID 16146581] rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder
- [PMID 19052197] rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.
[PMID 19132526] panic disorder with a possible gender-dependent effect
[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
[PMID 20331984] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes
[PMID 21396719] Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
[PMID 22693556] TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis
[PMID 22698518] Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
[PMID 16116490] Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.
[PMID 17176491] Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.
[PMID 17176492] Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.
[PMID 17346350] Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.
[PMID 17568567] Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.
[PMID 17892388] Genetic variation of serotonin function and cognitive control.
[PMID 18782386] Tryptophan hydroxylase 2 gene and alcohol use among college students.
[PMID 19077664] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
[PMID 19361870] TPH2 gene variants and anxiety during alcohol detoxification outcome.
[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
[PMID 20126463] Alternative splicing and extensive RNA editing of human TPH2 transcripts.
[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21418063] Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.
[PMID 22322887] Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.
[PMID 22392150] Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.
[PMID 22868061] The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism
[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants