Rs4570625

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Geno Mag Summary
(G;G) 2.5 higher scores on anxiety-related personality traits; greater placebo response
(G;T) normal
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position71938143
GeneTPH2
is asnp
is mentioned by
dbSNPrs4570625
Exacrs4570625
PheGenIrs4570625
nextbiors4570625
hapmaprs4570625
1000 genomesrs4570625
hgdprs4570625
ensemblrs4570625
gopubmedrs4570625
geneviewrs4570625
scholarrs4570625
googlers4570625
pharmgkbrs4570625
gwascentralrs4570625
openSNPrs4570625
23andMers4570625
23andMe allrs4570625
SNP Nexus

SNPshotrs4570625
SNPdbers4570625
MSV3drs4570625
GMAF0.3632
Max Magnitude2.5
? (G;G) (G;T) (T;T) 28
rs4570625, also known as G-703T, is a SNP in the tryptophan hydroxylase 2 TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:
  • rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission
  • [PMID 19052197] rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.

g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not

[PMID 19132526] panic disorder with a possible gender-dependent effect

Neighborrs11178997
Distance230
OMIM143465
DescATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
Variant
Relatedalso
OMIM607478
DescTRYPTOPHAN HYDROXYLASE 2; TPH2
Variant
Relatedalso

[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder


[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals


[PMID 20331984] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes

OMIM613003
Desc
Variant
Relatedalso


[PMID 21396719] Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia


[PMID 22693556OA-icon.png] TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis


[PMID 22698518] Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients

[PMID 16116490] Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

[PMID 17176491] Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

[PMID 17176492] Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

[PMID 17346350OA-icon.png] Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

[PMID 17568567] Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.

[PMID 17892388] Genetic variation of serotonin function and cognitive control.

[PMID 18782386OA-icon.png] Tryptophan hydroxylase 2 gene and alcohol use among college students.

[PMID 19077664OA-icon.png] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

[PMID 19361870] TPH2 gene variants and anxiety during alcohol detoxification outcome.

[PMID 19742166OA-icon.png] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 20126463OA-icon.png] Alternative splicing and extensive RNA editing of human TPH2 transcripts.

[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21418063] Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.

[PMID 22322887] Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

[PMID 22392150] Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.


[PMID 22868061] The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism


[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants


[PMID 24458851] Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches


[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.


[PMID 22835848] Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders.


[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.