Rs3900940

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Orientationplus
Geno Mag Summary
(C;C) increased risk of coronary heart disease; better response to statins
(C;T) increased risk of coronary heart disease; better response to statins
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome3
Position108428881
GeneMYH15
is asnp
is mentioned by
dbSNPrs3900940
Exacrs3900940
PheGenIrs3900940
nextbiors3900940
hapmaprs3900940
1000 genomesrs3900940
hgdprs3900940
ensemblrs3900940
gopubmedrs3900940
geneviewrs3900940
scholarrs3900940
googlers3900940
pharmgkbrs3900940
gwascentralrs3900940
openSNPrs3900940
23andMers3900940
23andMe allrs3900940
SNP Nexus

SNPshotrs3900940
SNPdbers3900940
MSV3drs3900940
GMAF0.1837
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs3900940 is a SNP in the MYH15 gene. The risk allele in terms of heart disease is rs3900940(C).

This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]



[PMID 19752551OA-icon.png] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry


[PMID 19023099OA-icon.png] Gene variants associated with ischemic stroke: the cardiovascular health study.


[PMID 19139070OA-icon.png] Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.


GET Evidence
MYH15-T1125A
aa_change Thr1125Ala
aa_change_short T1125A
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.241621
summary