Promethease 0.1.82

Rs363050

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is asnp
is mentioned by
dbSNPrs363050
hapmaprs363050
hgdprs363050
ensemblrs363050
gopubmedrs363050
scholarrs363050
googlers363050
pharmgkbrs363050
hgvbaseg2prs363050
medrefsnprs363050
23andMers363050
SNP Nexus

GeneSNAP25
Chromosome20
Orientationplus
Position10182257
GenotypeEffect
rs363050(A;A)
rs363050(A;G)
rs363050(G;G)


Genotypes Magnitude Summary
Rs363050(A;A) 1.11.1
Rs363050(A;G) 1.11.1
Rs363050(G;G) 0.10.1
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 16801949].

The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G) genotype (p=0.0002). Variance in this SNP may account for 3.4% of the phenotypic variance in PIQ.[PMID 16801949]

rs363050 is in close linkage with rs353016, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]

? (A;A) (A;G) (G;G)
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