Rs363050

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Orientationplus
Geno Mag Summary
(A;A) 1.1
(A;G) 1.1
(G;G) 0.1
ReferenceGRCh38 38.1/141
Chromosome20
Position10253609
GeneSNAP25
is asnp
is mentioned by
dbSNPrs363050
Exacrs363050
PheGenIrs363050
nextbiors363050
hapmaprs363050
1000 genomesrs363050
hgdprs363050
ensemblrs363050
gopubmedrs363050
geneviewrs363050
scholarrs363050
googlers363050
pharmgkbrs363050
gwascentralrs363050
openSNPrs363050
23andMers363050
23andMe allrs363050
SNP Nexus

SNPshotrs363050
SNPdbers363050
MSV3drs363050
GMAF0.4729
Max Magnitude1.1
? (A;A) (A;G) (G;G) 28
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 16801949].

The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G) genotype (p=0.0002). Variance in this SNP may account for 3.4% of the phenotypic variance in PIQ.[PMID 16801949]

rs363050 is in close linkage with rs353016, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]

Measures of Intelligence


[PMID 22762387] Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25