Rs363039

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Orientationminus
is asnp
is mentioned by
dbSNPrs363039
PheGenIrs363039
nextbiors363039
hapmaprs363039
1000 genomesrs363039
hgdprs363039
ensemblrs363039
gopubmedrs363039
geneviewrs363039
scholarrs363039
googlers363039
pharmgkbrs363039
gwascentralrs363039
openSNPrs363039
23andMers363039
23andMe allrs363039
SNP Nexus

SNPshotrs363039
SNPdbers363039
MSV3drs363039
GeneSNAP25
Chromosome20
Orientationminus
GMAF0.4467
Position10220496
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;G)
(C;C)
(T;T) 0
Make rs363039(C;T)
? (C;C) (C;T) (T;T) 28

This is one of four SNPs in the first intron of the SNAP25 gene that have been correlated with increased intelligence based on studies of ~300 Caucasian subjects.[PMID 16801949]

In orientation to the dbSNP entry for this SNP, rather than as published, the (C;C) genotype averages ~2 PIQ points higher than the (C;T) genotype, which averages 2 PIQ points higher than the (T;T) genotype.[PMID 16801949]

For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]


[PMID 20950795] The SNAP25 Gene Is Linked to Working Memory Capacity and Maturation of the Posterior Cingulate Cortex During Childhood


[PMID 22193912] Variants in SNAP25 are targets of natural selection and influence verbal performances in women


[PMID 23593184] DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.