Rs326

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Orientationplus
Geno Mag Summary
(A;A) 2 lower HDL cholesterol
(A;G) lower HDL cholesterol
(G;G) normal risk
ReferenceGRCh38 38.1/141
Chromosome8
Position19961928
GeneLPL
is asnp
is mentioned by
dbSNPrs326
PheGenIrs326
nextbiors326
hapmaprs326
1000 genomesrs326
hgdprs326
ensemblrs326
gopubmedrs326
geneviewrs326
scholarrs326
googlers326
pharmgkbrs326
gwascentralrs326
openSNPrs326
23andMers326
23andMe allrs326
SNP Nexus

SNPshotrs326
SNPdbers326
MSV3drs326
GMAF0.3457
Max Magnitude2
? (A;A) (A;G) (G;G) 28

The (A) allele of rs326 was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.[PMID 17952847OA-icon.png]

GWAS snp
PMID [PMID 18193046]
Trait Triglycerides
Title Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
Risk Allele A
P-val 4.9999999999999997E-12
Odds Ratio 6.60 [3.66-9.54] % higher
OMIM609708
DescLIPOPROTEIN LIPASE; LPL
Variant
Relatedalso


OMIM609708
Desc
Variant0042
Relatedalso
[PMID 21149302OA-icon.png] Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population


[PMID 15980532OA-icon.png] SOP3v2: web-based selection of oligonucleotide primer trios for genotyping of human and mouse polymorphisms.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 20150529OA-icon.png] Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study.


GET Evidence
rs326
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.390625
summary



GWAS snp
PMID [PMID 23726366OA-icon.png]
Trait Triglycerides
Title Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Risk Allele T
P-val 1E-8
Odds Ratio .04 [NR] unit decrease