Rs324650

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Orientationplus
is asnp
is mentioned by
dbSNPrs324650
PheGenIrs324650
nextbiors324650
hapmaprs324650
1000 genomesrs324650
hgdprs324650
ensemblrs324650
gopubmedrs324650
geneviewrs324650
scholarrs324650
googlers324650
pharmgkbrs324650
gwascentralrs324650
openSNPrs324650
23andMers324650
23andMe allrs324650
SNP Nexus

SNPshotrs324650
SNPdbers324650
MSV3drs324650
GeneCHRM2, LOC349160
Chromosome7
Orientationplus
GMAF0.4421
Position137008914
ReferenceGRCh38 38.1/141
Max Magnitude0.1
Geno Mag Summary
(A;A) 0
(A;T) 0.1
(T;T) 0.1
? (A;A) (A;T) (T;T) 28

In 2009, a large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2 [PMID 19418213].

Earlier work had observed that this snp (and perhaps its neighbors) influenced intelligence and alcohol dependence

[PMID 16000316] CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. And the earlier [PMID 15229186]

[PMID 17160701] and [PMID 17081262] or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324640, showed similar results to rs324650, and was in linkage disequilibrium (r2 = 0.90) with it. [PMID 17081262].

OMIM103780
DescALCOHOL DEPENDENCE
Variant
Relatedalso
OMIM608516
DescMAJOR DEPRESSIVE DISORDER; MDD
Variant
Relatedalso
OMIM118493
DescCHOLINERGIC RECEPTOR, MUSCARINIC, 2; CHRM2
Variant
Relatedalso

[PMID 19644963] Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction


[PMID 20351719OA-icon.png] Genetic variation in cholinergic muscarinic-2 receptor gene modulates M(2) receptor binding in vivo and accounts for reduced binding in bipolar disorder

[PMID 21176104] Association of CHRM2 polymorphisms with severity of alcohol dependence

[PMID 17373692OA-icon.png] No evidence for association between 19 cholinergic genes and bipolar disorder.

[PMID 17996044OA-icon.png] Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.

[PMID 18634760OA-icon.png] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.

[PMID 19181679] Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.