rs2814778 is within the DARC gene, which encodes the Duffy blood group antigen [PMID 7663520]. This SNP shows an almost perfectly fixed difference in frequency between Europeans and those with African ancestry. (One exception appears to be a certain population of Czech gypsies, and certain non-Ashkenazi Jewish populations.) Additionally the Namibian San samples of the CEPH-HGDP are, uncharacteristically for Africans, all AA homozygotes for this SNP.
The rs2814778 (G) allele is associated with African populations, while rs2814778 (A) is associated with European populations and southwestern Native American populations.
[PMID 19180233] rs2814778(G;G) protect against Plasmodium vivax malaria and predicts of white blood cell and neutrophil count
23andMe blog discussion
|Title||Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.|
|Odds Ratio||None None|
[PMID 22207676] The association between a Darc gene polymorphism and clinical outcomes in African Americans with acute lung injury
|Title||Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.|
|Odds Ratio||1.3500 None|
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[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
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[PMID 19758966] Ethnic and genetic causes of neutropenia: clinical and therapeutic implications.
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[PMID 21257350] DNA-based methods in the immunohematology reference laboratory.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
|Disease||DUFFY BLOOD GROUP SYSTEM Resistance to Plasmodium vivax infection White blood cell count quantitative trait locus 1|
|CLNDBN||DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE Resistance to Plasmodium vivax infection White blood cell count quantitative trait locus 1|
|CLNSRC||OMIM Allelic Variant dbRBC - Blood Group Antigen Gene Mutation Database|
|CLNACC||RCV000000006.2, RCV000000007.2, RCV000000008.1,|