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{{ population diversity | geno1=(C;C) | geno2=(C;T) | geno3=(T;T) | CEU | 29.2 | 44.2 | 26.5 | HCB | 60.6 | 36.5 | 2.9 | JPT | 44.2 | 44.2 | 11.5 | YRI | 12.2 | 39.5 | 48.3 | ASW | 24.6 | 40.4 | 35.1 | CHB | 60.6 | 36.5 | 2.9 | CHD | 58.7 | 33.9 | 7.3 | GIH | 21.8 | 41.6 | 36.6 | LWK | 20.9 | 47.3 | 31.8 | MEX | 44.8 | 41.4 | 13.8 | MKK | 11.5 | 52.6 | 35.9 | TSI | 19.6 | 50.0 | 30.4 | HapMapRevision=28 }}{{PMID|15759211}} Associated with [[nicotine Dependence]] as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans. The risk haplotype varies between populations. Among African-Americans, the haplotype C-C-G of [[rs2491397]]-[[rs2184026]]-[[rs3750344]] had a significant positive association with [[nicotine dependence]]. Among European-Americans, for [[rs1435252]]-[[rs3780422]]-[[rs2779562]]-[[rs3750344]], the C-A-C-A haplotype was positively associated with [[nicotine dependence]] while the T-A-T-A haplotype was negatively associated.{{PMID|15759211}} {{omim |id=607340 |desc=GAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2 |rsnum=2779562 }} {{omim |id=607340 |rsnum=2779562 |variant=0002 }} {{omim |id=607340 |rsnum=2779562 |variant=0003 }} {{PMID Auto |PMID=22309839 |Title=Association study of 45 candidate genes in nicotine dependence in Han Chinese }} {{on chip | 23andMe v1}} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}} {{on chip | Affy GenomeWide 6}} {{on chip | Affy500k}} {{on chip | FTDNA2}} {{on chip | FTDNA}} {{on chip | HumanOmni1Quad}}
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