Rs2619522

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Orientationminus
Geno Mag Summary
(G;G) 2 associated with lower attention capacity but also a decrease in positive and paranoid schizotypy scores
(T;T) 0
Make rs2619522(G;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position15653418
GeneDTNBP1
is asnp
is mentioned by
dbSNPrs2619522
Exacrs2619522
PheGenIrs2619522
nextbiors2619522
hapmaprs2619522
1000 genomesrs2619522
hgdprs2619522
ensemblrs2619522
gopubmedrs2619522
geneviewrs2619522
scholarrs2619522
googlers2619522
pharmgkbrs2619522
gwascentralrs2619522
openSNPrs2619522
23andMers2619522
23andMe allrs2619522
SNP Nexus

SNPshotrs2619522
SNPdbers2619522
MSV3drs2619522
GMAF0.2181
Max Magnitude2
? (G;G) (G;T) (T;T) 28
g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.


[PMID 19077176] Variation in the dysbindin gene and normal cognitive function in three independent population samples

[PMID 19252939] Dysbindin gene (DTNBP1) and schizophrenia in Korean population

OMIM607145
DescDYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
Variant
Relatedalso
[PMID 21130223OA-icon.png] Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability


[PMID 12098102OA-icon.png] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.


[PMID 12474144OA-icon.png] Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.


[PMID 15290652OA-icon.png] A powerful strategy to account for multiple testing in the context of haplotype analysis.


[PMID 15362017OA-icon.png] Association of the DTNBP1 locus with schizophrenia in a U.S. population.


[PMID 17033966OA-icon.png] Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.


[PMID 17074466OA-icon.png] DTNBP1 genotype influences cognitive decline in schizophrenia.


[PMID 17192893] Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder.


[PMID 17264804] Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy.


[PMID 17336946] Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level.


[PMID 17445278OA-icon.png] Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.


[PMID 17888175OA-icon.png] Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.


[PMID 17964051] Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.


[PMID 18562100] DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients.


[PMID 18663367OA-icon.png] The dystrobrevin-binding protein 1 gene: features and networks.


[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.


[PMID 18804346OA-icon.png] Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.


[PMID 19065121] Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors.


[PMID 19089808] Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS).


[PMID 20046352OA-icon.png] Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder.


[PMID 20822372] Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes.


[PMID 21305691] Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis.


[PMID 22580710OA-icon.png] The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.