g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.
[PMID 19077176] Variation in the dysbindin gene and normal cognitive function in three independent population samples
[PMID 19252939] Dysbindin gene (DTNBP1) and schizophrenia in Korean population[PMID 21130223] Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability
[PMID 12098102] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
[PMID 12474144] Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.
[PMID 15290652] A powerful strategy to account for multiple testing in the context of haplotype analysis.
[PMID 15362017] Association of the DTNBP1 locus with schizophrenia in a U.S. population.
[PMID 17033966] Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
[PMID 17074466] DTNBP1 genotype influences cognitive decline in schizophrenia.
[PMID 17192893] Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder.
[PMID 17264804] Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy.
[PMID 17336946] Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level.
[PMID 17445278] Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
[PMID 17888175] Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.
[PMID 17964051] Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.
[PMID 18562100] DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients.
[PMID 18663367] The dystrobrevin-binding protein 1 gene: features and networks.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 18804346] Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
[PMID 19065121] Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors.
[PMID 19089808] Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS).
[PMID 20046352] Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder.
[PMID 20822372] Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes.
[PMID 21305691] Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis.
[PMID 22580710] The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.