Rs2518224

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Orientationplus
is asnp
is mentioned by
dbSNPrs2518224
PheGenIrs2518224
nextbiors2518224
hapmaprs2518224
1000 genomesrs2518224
hgdprs2518224
ensemblrs2518224
gopubmedrs2518224
geneviewrs2518224
scholarrs2518224
googlers2518224
pharmgkbrs2518224
gwascentralrs2518224
openSNPrs2518224
23andMers2518224
23andMe allrs2518224
SNP Nexus

SNPshotrs2518224
SNPdbers2518224
MSV3drs2518224
GeneGRIK2
Chromosome6
Orientationplus
GMAF0.06933
Position101906652
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) 0 normal
(A;C) 0 normal
(C;C)
? (A;A) (A;C) (C;C) 28
This SNP, located in an intron of the GRIK2 gene, has been linked in one study to increased thoughts of suicide in patients using the anti-depressant drug citalopram. The risk is only seen for individuals carrying two rs2518224(C) alleles, i.e. the rs2518224(C;C) homozygotes. The odds ratio for these individuals is 8.2. If the individual also has at least one rs4825476(G) allele, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [PMID 17898344]



[PMID 19724244OA-icon.png] Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.


[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.


GET Evidence
rs2518224
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0703125
summary