Rs2298566

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Orientationplus
Geno Mag Summary
(A;A) 0 normal
(A;C) 2 increased risk of coronary heart disease; better response to statins
(C;C) increased risk of coronary heart disease; better response to statins
ReferenceGRCh38 38.1/141
Chromosome11
Position130880747
GeneSNX19
is asnp
is mentioned by
dbSNPrs2298566
PheGenIrs2298566
nextbiors2298566
hapmaprs2298566
1000 genomesrs2298566
hgdprs2298566
ensemblrs2298566
gopubmedrs2298566
geneviewrs2298566
scholarrs2298566
googlers2298566
pharmgkbrs2298566
gwascentralrs2298566
openSNPrs2298566
23andMers2298566
23andMe allrs2298566
SNP Nexus

SNPshotrs2298566
SNPdbers2298566
MSV3drs2298566
GMAF0.2236
Max Magnitude2
? (A;A) (A;C) (C;C) 28
rs2298566 is a SNP in the MYH15 gene. The risk allele in terms of heart disease is rs2298566(C).

This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]



[PMID 19752551OA-icon.png] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.


GET Evidence
SNX19-L878R
aa_change Leu878Arg
aa_change_short L878R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.808701
summary