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{{ population diversity | geno1=(C;C) | geno2=(C;G) | geno3=(G;G) | CEU | 58.5 | 32.3 | 9.2 | HCB | 6.7 | 22.2 | 71.1 | JPT | 0.0 | 31.8 | 68.2 | YRI | 54.0 | 33.3 | 12.7 | ASW | 0.0 | 0.0 | 0.0 | CHB | 6.7 | 22.2 | 71.1 | CHD | 0.0 | 0.0 | 0.0 | GIH | 0.0 | 0.0 | 0.0 | LWK | 0.0 | 0.0 | 0.0 | MEX | 0.0 | 0.0 | 0.0 | MKK | 0.0 | 0.0 | 0.0 | TSI | 0.0 | 0.0 | 0.0 | HapMapRevision=28 }}[[rs2297508]] is one of several SNPs associated with the [[SREBF1]] gene that show a modest association with [[type-2 diabetes]]. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, [[rs2297508]](C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001).{{PMID|18192539}} {{PMID|18692268}} [[type-2 diabetes]] [[rs2297508]](C) and [[rs11868035]](C) {{ neighbor | rsid = 11868035 | distance = 216 }} {{PMID Auto |PMID=21178094 |Title=A Two-Step Association Study Identifies CAV2 rs2270188 Single Nucleotide Polymorphism Interaction with Fat Intake in Type 2 Diabetes Risk }} {{PMID Auto |PMID=21609284 |Title=Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth }} {{PMID Auto |PMID=22678801 |Title=[Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population] }} {{PMID Auto |PMID=17160088 |Title=The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population. }} {{on chip | HumanOmni1Quad}}
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