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rs2272382, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.3 kg/m(2), p= 0.016). When two populations were combined, totaling ~1200 patients, the risk allele (rs2272382(A) averaged an increase of 0.35 (â€“0.14 to 0.83).[PMID 16443771]
A follow-up study of 1,680 middle-aged Dutch women found that compared with non-carriers, both rs2272382(A;G) heterozygotes and (A;A) homozygotes derived less energy from fat ((A;G): -0.55+/-0.28%, p=0.05; (A;A): -0.95+/-0.48%, p=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates (0.69+/-0.33%, p= 0.04 and 1.68+/-0.56%, p= 0.003, respectively), mainly because of a higher consumption of mono- and disaccharides. Both this SNP, rs2272382, as well as a linked SNP, rs1528133, were also associated with a higher glycemic load in the diet. The glycemic load was higher among those with rs2272382(A;G) and (A;A) genotypes than among (G;G) homozygotes (+1.49, CI: -0.27-3.24, and +3.89, CI: 0.94-6.85 units, respectively).[PMID 18183286]