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{{ population diversity | geno1=(A;A) | geno2=(A;G) | geno3=(G;G) | CEU | 3.2 | 46.0 | 50.8 | HCB | 6.7 | 71.1 | 22.2 | JPT | 11.4 | 45.5 | 43.2 | YRI | 25.8 | 41.9 | 32.3 | ASW | 0.0 | 0.0 | 0.0 | CHB | 6.7 | 71.1 | 22.2 | CHD | 0.0 | 0.0 | 0.0 | GIH | 0.0 | 0.0 | 0.0 | LWK | 0.0 | 0.0 | 0.0 | MEX | 0.0 | 0.0 | 0.0 | MKK | 0.0 | 0.0 | 0.0 | TSI | 0.0 | 0.0 | 0.0 | HapMapRevision=28 }}[[rs2272382]], a SNP in the [[TUB]] gene, was found in a study of 492 unrelated [[type-2 diabetes]] patients to have a significant effect on body mass index and thus [[obesity]] (1.3 kg/m(2), p= 0.016). When two populations were combined, totaling ~1200 patients, the risk allele ([[rs2272382]](A) averaged an increase of 0.35 (–0.14 to 0.83).{{PMID|16443771}} A follow-up study of 1,680 middle-aged Dutch women found that compared with non-carriers, both [[rs2272382]](A;G) heterozygotes and (A;A) homozygotes derived less energy from fat ((A;G): -0.55+/-0.28%, p=0.05; (A;A): -0.95+/-0.48%, p=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates (0.69+/-0.33%, p= 0.04 and 1.68+/-0.56%, p= 0.003, respectively), mainly because of a higher consumption of mono- and disaccharides. Both this SNP, [[rs2272382]], as well as a linked SNP, [[rs1528133]], were also associated with a higher glycemic load in the diet. The glycemic load was higher among those with [[rs2272382]](A;G) and (A;A) genotypes than among (G;G) homozygotes (+1.49, CI: -0.27-3.24, and +3.89, CI: 0.94-6.85 units, respectively).{{PMID|18183286}} {{PMID Auto |PMID=17955208 |Title=TUB is a candidate gene for late-onset obesity in women. }} {{PMID Auto |PMID=19759915 |Title=Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. }} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}}
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