Rs2235067

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Orientationplus
is asnp
is mentioned by
dbSNPrs2235067
PheGenIrs2235067
nextbiors2235067
hapmaprs2235067
1000 genomesrs2235067
hgdprs2235067
ensemblrs2235067
gopubmedrs2235067
geneviewrs2235067
scholarrs2235067
googlers2235067
pharmgkbrs2235067
gwascentralrs2235067
openSNPrs2235067
23andMers2235067
23andMe allrs2235067
SNP Nexus

SNPshotrs2235067
SNPdbers2235067
MSV3drs2235067
GeneABCB1
Chromosome7
Orientationplus
GMAF0.1226
Position87520606
ReferenceGRCh38 38.1/141
Max Magnitude2
Geno Mag Summary
(A;A) 1 7x more likely to respond to certain antidepressants
(A;G) 1 7x more likely to respond to certain antidepressants
(G;G) 2 7x less likely to respond to certain antidepressants
? (A;A) (A;G) (G;G) 28
rs2235067 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2235067 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs2235067(G) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:

[PMID 18424454OA-icon.png] ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.