Join us in the chatroom

Rs2235015

From SNPedia
Jump to: navigation, search

Orientationplus
is asnp
is mentioned by
dbSNPrs2235015
PheGenIrs2235015
nextbiors2235015
hapmaprs2235015
1000 genomesrs2235015
hgdprs2235015
ensemblrs2235015
gopubmedrs2235015
geneviewrs2235015
scholarrs2235015
googlers2235015
pharmgkbrs2235015
gwascentralrs2235015
openSNPrs2235015
23andMers2235015
23andMe allrs2235015
SNP Nexus

SNPshotrs2235015
SNPdbers2235015
MSV3drs2235015
GeneABCB1
Chromosome7
Orientationplus
GMAF0.202
Position87570248
ReferenceGRCh38 38.1/141
Max Magnitude0
Geno Mag Summary
(G;G) 0 7x more likely to respond to certain antidepressants
(G;T) 7x more likely to respond to certain antidepressants
(T;T) 7x less likely to respond to certain antidepressants
? (G;G) (G;T) (T;T) 28
rs2235015 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2032583 is near 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below. rs2235015 has an r2 value of >0.5 with this group.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs2235015(T) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:



[PMID 18382661OA-icon.png] Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample.


[PMID 18535201OA-icon.png] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 22641028] ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder.


GET Evidence
rs2235015
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.247769
summary



[PMID 22672924] Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas