Rs1954787

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Orientationplus
is asnp
is mentioned by
dbSNPrs1954787
PheGenIrs1954787
nextbiors1954787
hapmaprs1954787
1000 genomesrs1954787
hgdprs1954787
ensemblrs1954787
gopubmedrs1954787
geneviewrs1954787
scholarrs1954787
googlers1954787
pharmgkbrs1954787
gwascentralrs1954787
openSNPrs1954787
23andMers1954787
23andMe allrs1954787
SNP Nexus

SNPshotrs1954787
SNPdbers1954787
MSV3drs1954787
GeneGRIK4
Chromosome11
Orientationplus
GMAF0.4679
Position120663363
ReferenceGRCh37 37.1/131
Max Magnitude2
Geno Mag Summary
(C;C) ~10% more likely to respond to citalopram
(C;T) 0 normal risk
(T;T) 2 ~10% less likely to respond to citalopram
? (C;C) (C;T) (T;T) 28
rs1954787, located in an intron of the GRIK4 gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. [PMID 17671280]

From the abstract of this article:

"The effect size of (this) GRIK4 marker alone was modest, but homozygote carriers of the treatment-response-associated marker alleles of both the GRIK4 and HTR2A (see rs7997012) genes were 23% less likely to experience nonresponse to (citalopram) treatment relative to participants who did not carry any of these marker alleles."


[PMID 19924111OA-icon.png] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment



[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21208417OA-icon.png] International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.


GET Evidence
rs1954787
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.375
summary



[PMID 23394390] Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response