rs1805008, known as Arg160Trp or R160W, is one of several SNPs in the MC1R gene associated with red hair color (redheads), in this case in an Irish population [PMID 9665397] although this has also been reported in Icelandic and Dutch populations [PMID 18488028].
The risk allele is rs1805008(T), compared with the wild-type rs1805008(C) allele.
blog about designing melanocortin analogs specific to these genotypes.
See also OMIM 155555.0005
|Disease||Skin/hair/eye pigmentation 2, Increased analgesia from kappa-opioid receptor agonist, OCULOCUTANEOUS ALBINISM|
|CLNDBN||Skin/hair/eye pigmentation 2, red hair/fair skin, Increased analgesia from kappa-opioid receptor agonist, female-specific, OCULOCUTANEOUS ALBINISM, TYPE II, MODIFIER OF|
|CLNSRC||OMIM Allelic Variant|
|CLNACC||RCV000015381.1, RCV000015382.1, RCV000015383.1|
[PMID 17999355] A genomewide association study of skin pigmentation in a South Asian population.
[PMID 18392143] Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects.
[PMID 20042077] Genetic determinants of hair and eye colours in the Scottish and Danish populations.
[PMID 20585627] Web-based, participant-driven studies yield novel genetic associations for common traits.
[PMID 20670983] The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
[PMID 23100201] A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
[PMID 23393597] Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study