Rs1726866

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Orientationminus
Geno Mag Summary
(C;C) 0.1 can taste bitter
(C;T) 0.1 can taste bitter
(T;T) 1.1 possible unable to taste bitter
ReferenceGRCh38 38.1/141
Chromosome7
Position141972905
GeneMGAM, TAS2R38
is asnp
is mentioned by
dbSNPrs1726866
PheGenIrs1726866
nextbiors1726866
hapmaprs1726866
1000 genomesrs1726866
hgdprs1726866
ensemblrs1726866
gopubmedrs1726866
geneviewrs1726866
scholarrs1726866
googlers1726866
pharmgkbrs1726866
gwascentralrs1726866
openSNPrs1726866
23andMers1726866
23andMe allrs1726866
SNP Nexus

SNPshotrs1726866
SNPdbers1726866
MSV3drs1726866
GMAF0.4082
Max Magnitude1.1
? (C;C) (C;T) (T;T) 28
rs1726866 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).

The rs1726866(C) allele is the "tasting" allele, and it is dominant to the "non-tasting" allele rs1726866(T), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one rs713598(G) and one rs10246939(C) allele since, along with rs1726866(C), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.[PMID 12595690]

[PMID 19782709OA-icon.png] (C;C) women showed a lower tendency to overeat. (T;T) women showed a greater tendency to overeat.

Neighborrs10246939
Distance101
OMIM607751
DescTASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
Variant
Relatedalso
OMIM607751
Desc
Variant0002
Relatedalso


ClinVar
Risk rs1726866(T;T)
Alt rs1726866(T;T)
Reference rs1726866(C;C)
Significance Drug-response
Disease Phenylthiocarbamide tasting
Variation info
Gene TAS2R38
CLNDBN Phenylthiocarbamide tasting
Reversed 1
HGVS NC_000007.13:g.141672705G\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000003039.1,



[PMID 15883422] TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.


[PMID 18248681OA-icon.png] Prevalence of common disease-associated variants in Asian Indians.


[PMID 18834969OA-icon.png] A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.


[PMID 19092995OA-icon.png] Bitter taste receptors influence glucose homeostasis.


[PMID 19779476OA-icon.png] Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.


GET Evidence
TAS2R38-A262V
aa_change Ala262Val
aa_change_short A262V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.473415
summary



[PMID 24083639] Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk


[PMID 23133589OA-icon.png] Bitter taste receptor polymorphisms and human aging.