rs1726866 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).
The rs1726866(C) allele is the "tasting" allele, and it is dominant to the "non-tasting" allele rs1726866(T), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one rs713598(G) and one rs10246939(C) allele since, along with rs1726866(C), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.[PMID 12595690]
[PMID 19782709] (C;C) women showed a lower tendency to overeat. (T;T) women showed a greater tendency to overeat.
|CLNSRC||ClinVar OMIM Allelic Variant|
[PMID 15883422] TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.
[PMID 18248681] Prevalence of common disease-associated variants in Asian Indians.
[PMID 18834969] A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.
[PMID 19092995] Bitter taste receptors influence glucose homeostasis.
[PMID 19779476] Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 24083639] Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk
[PMID 23133589] Bitter taste receptor polymorphisms and human aging.