| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
risk of progressing from IGT to T2D; reduced by exercise
|
| (C;G)
|
|
risk of progressing from IGT to T2D; reduced by exercise
|
| (G;G)
|
|
normal
|
| ? | (C;C) (C;G) (G;G) | 28 |
|---|
 |
is a SNP in the peroxisome proliferator-activated receptor gamma
PPARG gene.
In a 4 year study of 479 overweight individuals with impaired glucose tolerance (IGT) who participated in the Finnish Diabetes Prevention Study (DPS), carrying a rs17036314(C) allele predicted conversion to type-2 diabetes (T2D) after adjustment for baseline fasting glucose (p=0.030). Increased physical activity reduced this risk.[PMID 18091023]
