Rs12720067

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Orientationminus
Geno Mag Summary
(A;A) 7x more likely to respond to certain antidepressants
(A;G) 7x more likely to respond to certain antidepressants
(G;G) 0 7x less likely to respond to certain antidepressants
ReferenceGRCh38 38.1/141
Chromosome7
Position87540040
GeneABCB1
is asnp
is mentioned by
dbSNPrs12720067
Exacrs12720067
PheGenIrs12720067
nextbiors12720067
hapmaprs12720067
1000 genomesrs12720067
hgdprs12720067
ensemblrs12720067
gopubmedrs12720067
geneviewrs12720067
scholarrs12720067
googlers12720067
pharmgkbrs12720067
gwascentralrs12720067
openSNPrs12720067
23andMers12720067
23andMe allrs12720067
SNP Nexus

SNPshotrs12720067
SNPdbers12720067
MSV3drs12720067
GMAF0.08081
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs12720067 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs12720067 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs12720067(G) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:



[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.


[PMID 18382661OA-icon.png] Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample.


GET Evidence
rs12720067
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0859375
summary