| ? | (A;A) (A;C) (C;C) | 28 |
|---|
 |
| Rs10946398
|
| PubMed
|
[PMID 17463249]
|
| Affy Probeset
|
SNP_A-4253796
|
| Affy Orientation
|
reverse
|
| On GW 5.0
|
1
|
| Alleles A/B
|
G/T
|
| Ancestral
|
C
|
| Population
|
EU (UK)
|
| Allele
|
C
|
| Case Freq.
|
|
| Control Freq.
|
|
| Odds Ratio Het
|
|
| Odds Ratio Hom
|
|
| Odds Ratio All
|
1.14
|
| Disease
|
Type II Diabetes (T2D)
|
rs10946398 increases susceptibility to Type II Diabetes 1.14 times for carriers of the C allele [PMID 17463249]
| GWAS snp
|
| PMID
|
[PMID 19056611]
|
| Trait
|
Type 2 diabetes
|
| Title
|
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|
| Risk Allele
|
|
| P-val
|
7E-7
|
| Odds Ratio
|
1.18 [1.11-1.26]
|
| OMIM | 611259 |
| Desc | CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1-LIKE 1; CDKAL1 |
| Variant | |
| Related | also |
[PMID 21673421] Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series
[PMID 21611789] The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel
