Rs10946398

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Orientationplus
Make rs10946398(A;A)
Make rs10946398(A;C)
Make rs10946398(C;C)
ReferenceGRCh37 37.1/131
Chromosome6
Position20661034
GeneCDKAL1
is asnp
is mentioned by
dbSNPrs10946398
Exacrs10946398
PheGenIrs10946398
nextbiors10946398
hapmaprs10946398
1000 genomesrs10946398
hgdprs10946398
ensemblrs10946398
gopubmedrs10946398
geneviewrs10946398
scholarrs10946398
googlers10946398
pharmgkbrs10946398
gwascentralrs10946398
openSNPrs10946398
23andMers10946398
23andMe allrs10946398
SNP Nexus

SNPshotrs10946398
SNPdbers10946398
MSV3drs10946398
Max Magnitude
? (A;A) (A;C) (C;C) 28
Rs10946398
PubMed [PMID 17463249]
Affy Probeset SNP_A-4253796
Affy Orientation reverse
On GW 5.0 1
Alleles A/B G/T
Ancestral C
Population EU (UK)
Allele C
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.14
Disease Type II Diabetes (T2D)


Neighborrs7754840
Distance216

rs10946398 increases susceptibility to Type II Diabetes 1.14 times for carriers of the C allele [PMID 17463249]

GWAS
SNP rs10946398
PubMedID [PMID 17463249]
Condition Type 2 diabetes
Gene CDKAL1
Risk Allele C
pValue 4.00E-011
OR 1.12
95% CI 1.08-1.16


GWAS snp
PMID [PMID 19056611]
Trait Type 2 diabetes
Title Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
Risk Allele
P-val 7E-7
Odds Ratio 1.18 [1.11-1.26]
OMIM611259
DescCDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1-LIKE 1; CDKAL1
Variant
Relatedalso




OMIM611259
Desc
Variant0001
Relatedalso


[PMID 21673421] Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series


[PMID 21611789] The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel