Warning: You are not logged in. Your IP address will be recorded in this page's edit history.
Free text:
{{ population diversity | geno1=(A;A) | geno2=(A;C) | geno3=(C;C) | CEU | 1.8 | 22.3 | 75.9 | HCB | 21.2 | 44.5 | 34.3 | JPT | 15.0 | 52.2 | 32.7 | YRI | 2.1 | 13.7 | 84.2 | ASW | 0.0 | 22.8 | 77.2 | CHB | 21.2 | 44.5 | 34.3 | CHD | 17.6 | 54.6 | 27.8 | GIH | 9.9 | 34.7 | 55.4 | LWK | 0.9 | 14.7 | 84.4 | MEX | 10.3 | 55.2 | 34.5 | MKK | 0.0 | 24.0 | 76.0 | TSI | 2.0 | 22.5 | 75.5 | HapMapRevision=28 }}{{neighbor | rsid = 1801028 | distance = 204 }}{{ neighbor | rsid = 1800496 | distance = 200 }} [[rs1076560]] is located in intron 6 of the dopamine receptor D2 gene. In one study of Japanese males, [[rs1076560]](A) alleles were 1.3 fold more associated with [[Alcoholism]] than the [[rs1076560]](C) alleles. {{PMID|17196743}} The [[DRD2]] risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify [[rs1076560]] as a potentially important variable in the development of [[alcoholism]]. {{PMID|19176830}} rs1076560 and the DAT 3'-VNTR variant influences [[memory]] {{PMID|19373123}} Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate [[addiction]] and the dosage requirements of methadone substitution {{PMID Auto |PMID=19796663 |Title=Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients }} {{PMID Auto |PMID=19940176 |Title=Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans }} {{PharmGKB |RSID=rs1076560 |Name_s= |Gene_s=DRD2 |Feature= |Evidence=PubMed ID:17196743 |Annotation=This variant is a potential marker for alcoholism. A allele was more prevalent in the alcoholic patients than in the healthy controls in a study consists of 248 alcoholic patients and 322 healthy controls (all Japanese males). |Drugs=ethanol |Drug Classes= |Diseases=Alcoholism |Curation Level=Curated |PharmGKB Accession ID=PA162360621 }} {{PMID Auto |PMID=19512960 |Title=Genetic diagnostics of functional variants of the human dopamine D2 receptor gene }} {{PMID Auto |PMID=20179754 |Title=Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance }} {{PMID Auto |PMID=19393722 |Title= Genetic contributions to avoidance-based decisions: striatal D2 polymorphisms }} {{PharmGKB |RSID=rs1076560 |Name_s= |Gene_s=DRD2 |Feature= |Evidence=PubMed ID:18077375; PubMed ID:18829695 |Annotation=This variant is in intron 6, and T allele shifts mRNA splicing from the short form (D2S) to the long form (D2L). The T allele carriers are also associated with reduced working memory and attension perfermance. |Drugs= |Drug Classes= |Diseases=Schizophrenia |Curation Level=Curated |PharmGKB Accession ID=PA162355758 }} {{PMID Auto |PMID=21087673 |Title=D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans }} {{PMID Auto |PMID=21150907 |Title=Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. }} {{PMID Auto |PMID=22569179 |Title=Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese }} {{PMID Auto |PMID=22745721 |Title=Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study }} {{PMID Auto |PMID=18077373 |Title=Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. }} {{PMID Auto |PMID=19321766 |Title=Dopamine DRD2 polymorphism alters reversal learning and associated neural activity. }} {{PMID Auto |PMID=20146828 |Title=Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. }} {{PMID Auto |PMID=20617039 |Title=Alcoholism and alternative splicing of candidate genes. }} {{PMID Auto |PMID=21187413 |Title=DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia. }} {{PMID Auto |PMID=21645585 |Title=Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype. }} {{GET Evidence |impact=pharmacogenetic |qualified_impact=Insufficiently evaluated pharmacogenetic |inheritance=unknown |quality_scores=Array |dbsnp_id=rs1076560 |overall_frequency_n=24 |overall_frequency_d=128 |overall_frequency=0.1875 |n_genomes=15 |n_genomes_annotated=0 |n_haplomes=18 |n_articles=1 |n_articles_annotated=0 |in_pharmgkb=Y |autoscore=1 |webscore=N }} {{ on chip | 23andMe v1 }} {{ on chip | Illumina Human 1M }} {{on chip | 23andMe v1}} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}} {{on chip | FTDNA2}} {{on chip | HumanOmni1Quad}} {{on chip | Illumina Human 1M}}
Edit Summary
Cancel
