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{{ population diversity | geno1=(A;A) | geno2=(A;G) | geno3=(G;G) | CEU | 38.9 | 43.4 | 17.7 | HCB | 10.9 | 49.6 | 39.4 | JPT | 15.9 | 46.0 | 38.1 | YRI | 29.3 | 53.1 | 17.7 | ASW | 31.6 | 56.1 | 12.3 | CHB | 10.9 | 49.6 | 39.4 | CHD | 9.2 | 44.0 | 46.8 | GIH | 11.9 | 36.6 | 51.5 | LWK | 21.8 | 46.4 | 31.8 | MEX | 19.0 | 48.3 | 32.8 | MKK | 23.1 | 51.9 | 25.0 | TSI | 33.3 | 51.0 | 15.7 | HapMapRevision=28 }}{{PMID|17440435}} [[schizophrenia]] [[rs1049623]] associated with schizophrenia (odds ratio=1.44, 95% confidence interval: 1.15-1.79, adjusted P=0.0016). {{PMID|17440435}} [[schizophrenia]] the SNPs ([[rs1049623]], [[rs2267641]] and [[rs2239518]]) haplotype remaining significant even after adjustment for multiple testing (adjusted P=0.0136). {{ neighbor | rsid = 2267641 | distance = 375 }} {{PharmGKB |RSID=rs1049623 |Name_s=exon 15 V599V, c.1908T>C, c.1797T>C, mRNA 2130T>C, mRNA 2167T>C, mRNA 1950T>C, p.Val599Val, p.Val636Val |Gene_s=DDR1 |Feature= |Evidence=PubMed ID:19837266 |Annotation=Risk or phenotype-associated allele, tested allele: unspecified; minor allele designation varies by ethnicity in dbSNP Phenotype: In 114 cases and 414 controls (n = 528), univariate analysis of disease association showed OR = 0.69 for heterozygote, OR = 1.04 for homozygous, versus homozygous wild type, in ALL, with P(trend) OR = 0.96, p = 0.78 using an additive model. Study size: 528. Study population/ethnicity: Childhood acute lymphoblastic leukemia (<=14 years) and healthy newborn controls (1988 to 1999) from South Wales in the United Kingdom. Significance metric(s): Non-significant finding p = 0.78. Type of association: CO. |Drugs= |Drug Classes= |Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma |Curation Level=Curated |PharmGKB Accession ID=PA165110231 }} {{GET Evidence |impact=pharmacogenetic |qualified_impact=Insufficiently evaluated pharmacogenetic |inheritance=unknown |quality_scores=Array |dbsnp_id=rs1049623 |overall_frequency_n=4353 |overall_frequency_d=10758 |overall_frequency=0.404629 |n_genomes=38 |n_genomes_annotated=0 |n_haplomes=49 |n_articles=1 |n_articles_annotated=0 |in_pharmgkb=Y |autoscore=1 |webscore=N }} {{ on chip | 23andMe v1 }} {{ on chip | Illumina Human 1M}} {{on chip | 23andMe v1}} {{on chip | 23andMe v2}} {{on chip | 23andMe v3}} {{on chip | FTDNA2}} {{on chip | HumanOmni1Quad}} {{on chip | Illumina Human 1M}}
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