rs1024611, also known as the -2578A>G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1 CCL2 gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses.
In a study focusing on 679 apparently healthy siblings of people with premature heart disease, investigators found that carriers of an rs1024611(C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with heart disease.[PMID 16934270]
[PMID 19032966] rs1024611 is not associated with systemic sclerosis in a multicenter study of 345 European patients
[PMID 23166687] [The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance]
[PMID 22142522] Lack of Association between rs1024611 (-2581 A/G) Polymorphism in CC-chemokine Ligand 2 and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
[PMID 22117412] [Association of polymorphic markers of CCL2 gene with essential hypertension]
[PMID 22384203] MCP1 SNPs and Pulmonary Tuberculosis in Cohorts from West Africa, the USA and Argentina: Lack of Association or Epistasis with IL12B Polymorphisms
[PMID 22733495] Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population
[PMID 16078996] Association study of functional genetic variants of innate immunity related genes in celiac disease.
[PMID 16672419] Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
[PMID 16719905] Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.
[PMID 17062130] Polymorphisms within inflammatory genes and colorectal cancer.
[PMID 17763208] Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population.
[PMID 17848170] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.
[PMID 17903293] Genome-wide association with select biomarker traits in the Framingham Heart Study.
[PMID 18464913] A genome-wide association study identifies protein quantitative trait loci (pQTLs).
[PMID 18698231] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
[PMID 18940815] MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa.
[PMID 19347053] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.
[PMID 19357773] Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.
[PMID 19506371] Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis.
[PMID 20111728] Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.
[PMID 20111745] Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.
[PMID 20125127] The -A2518G polymorphism of monocyte chemoattractant protein-1 is associated with Crohn's disease.
[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
[PMID 20339010] CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage.
[PMID 20622166] Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
[PMID 20725607] CCL3 genotype and current depression increase risk of HIV-associated dementia.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 22425139] Monocyte chemoattractant protein-1 in schizophrenia: -2518A/G genetic variant and protein levels in Armenian population.
[PMID 23166687] The rs1024611 Regulatory Region Polymorphism Is Associated with CCL2 Allelic Expression Imbalance
[PMID 23427179] Relationships of Single Nucleotide Polymorphisms of Monocyte Chemoattractant Protein 1 and Chemokine Receptor 2 With Susceptibility and Clinicopathologic Characteristics of Neoplasia of Uterine Cervix in Taiwan Women
[PMID 24023637] Gender-Specific Effects of Genetic Variants within Th1 and Th17 Cell-Mediated Immune Response Genes on the Risk of Developing Rheumatoid Arthritis
[PMID 24083412] Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
[PMID 24382482] Polymorphism of monocyte chemoattractant protein -1 (MCP-1 -2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients
[PMID 24786287] No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population
[PMID 24968246] Relationship between MCP-1 promoter -2518 A/G gene polymorphism (rs1024611) and systemic lupus erythematosus/lupus nephritis
[PMID 25119828] The CC chemokine ligand 2 (CCL2) polymorphism -2518A/G is associated with gout in the Chinese Han male population
[PMID 25413568] The associations between the MCP-1 -2518 A/G polymorphism and ischemic heart disease and ischemic stroke: a meta-analysis of 28 research studies involving 21,524 individuals