From SNPedia
This SNP, located on chromosome 2 in a gene (
VAMP8) associated with platelet activation, may be associated with early onset
myocardial infarction (MI). The risk allele for this SNP (in dbSNP orientation) is
rs1010(G), with an odds ratio of 1.75 (CI: 1.17–2.62). [
PMID 16690874]
Furthermore, this SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).
For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]
| ? | (A;A) (A;G) (G;G) |
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[PMID 19752551] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry
