Genoset

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A genoset refers to a defined set of genotypes; we have coined the term to represent the combination of alleles at 2 or more loci, especially when they are not contiguous along a chromosome. Typically, these are then related to a medical (or ancestral) consequence that arises only when a particular combination of SNPs is inherited.

Promethease understands this criteria syntax.

More information about genosets can be found in the related SNPedia blog post. Note that genosets themselves are boolean, not quantitative; each genoset is either true (present) or false (absent) in an individual, based on the genoset's criteria, in the same way that a genotype (or allele) is either present or absent. Note that if a DNA microarray platform lacks a given SNP, genosets that require it (that SNP) will not return a result during a Promethease evaluation.

Most Significant

 ReputeMagnitudeSummaryModification dateThis property is a special property in this wiki.
Gs14910testing for orientation issues8 May 2009 03:43:00
Gs2676APOE1/APOE111 October 2013 05:15:46
Gs216Bad62 copies of the APO-ε4 allele10 August 2014 21:44:23
Gs2286sickle cell affected25 October 2012 02:21:38
Gs2615Help us fix a bug in SNPedia30 July 2014 21:16:19
Gs1215DR3/4-DQ8 individual at high risk for type-1 diabetes21 October 2011 06:04:16
Gs254Bad4.1Pseudocholinesterase Deficiency25 October 2012 02:24:20
Gs1454Female24 March 2014 20:03:48
Gs251Bad43x increased risk of venous thrombosis3 October 2014 17:11:09
Gs245Bad44x increased risk for esophageal squamous cell cancer among Han Chinese21 October 2011 06:04:36
... further results


Most Recently Active

 ReputeMagnitudeSummaryModification dateThis property is a special property in this wiki.
Gs251Bad43x increased risk of venous thrombosis3 October 2014 17:11:09
Gs219Bad4Hemochromatosis2 October 2014 19:13:37
Gs1703CYP2D6*8 double24 September 2014 17:38:24
Gs2601some variation related to eye color24 September 2014 15:04:03
Gs1892.5probably APOE E2/E4, but maybe E1/E3. E1 is the 'missing APOE allele'15 September 2014 02:17:03
Gs216Bad62 copies of the APO-ε4 allele10 August 2014 21:44:23
Gs2562.5Blue eyes1 August 2014 11:39:11
Gs2615Help us fix a bug in SNPedia30 July 2014 21:16:19
Gs141Bad3.52x risk of Alzheimer's disease21 July 2014 18:47:00
Gs2702APOE E2/E4 or possibly E1/E321 July 2014 18:44:58
... further results


You can create a new genoset by clicking that link and filling in the form. But you'll still need to populate the criteria syntax.