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Genoset

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A genoset refers to a defined set of genotypes; we have coined the term to represent the combination of alleles at 2 or more loci, especially when they are not contiguous along a chromosome. Typically, these are then related to a medical (or ancestral) consequence that arises only when a particular combination of SNPs is inherited.

Promethease understands this criteria syntax.

More information about genosets can be found in the related SNPedia blog post. Note that genosets themselves are boolean, not quantitative; each genoset is either true (present) or false (absent) in an individual, based on the genoset's criteria, in the same way that a genotype (or allele) is either present or absent. Note that if a DNA microarray platform lacks a given SNP, genosets that require it (that SNP) will not return a result during a Promethease evaluation.

Most Significant

 ReputeMagnitudeSummaryModification date
This property is a special property in this wiki.
Gs14910testing for orientation issues8 May 2009 03:43:00
Gs2286sickle cell affected25 October 2012 02:21:38
Gs2676APOE1/APOE111 October 2013 05:15:46
Gs216Bad62 copies of the APO-ε4 allele10 August 2014 21:44:23
Gs1215DR3/4-DQ8 individual at high risk for type-1 diabetes21 October 2011 06:04:16
Gs2615Help us fix a bug in SNPedia30 July 2014 21:16:19
Gs254Bad4.1Pseudocholinesterase Deficiency25 October 2012 02:24:20
Gs245Bad44x increased risk for esophageal squamous cell cancer among Han Chinese21 October 2011 06:04:36
Gs293Bad4increased risk of Alzheimer's disease, consider reducing iron levels29 May 2014 18:37:35
Gs1174risk of type-1 diabetes21 October 2011 06:04:12
... further results


Most Recently Active

 ReputeMagnitudeSummaryModification date
This property is a special property in this wiki.
Gs298Bad2.5Increased surveillance for colorectal cancer recommended16 April 2015 03:36:00
Gs2662.5Data Quality Warning24 March 2015 02:50:12
Gs162Bad3.3CYP2C9 Poor Metabolizers5 March 2015 14:46:46
Gs1961.6Haplogroup I (Y-DNA); 50% higher age-adjusted risk of coronary artery disease?3 March 2015 00:23:31
Gs224Bad3Two copies of GCH1 variant associated with lower levels of tetrahydrobiopterin21 February 2015 05:47:35
Gs291Good3Lower heart attack risk than average12 February 2015 02:46:01
Gs297Good2.4Lower heart attack risk than average12 February 2015 02:23:24
Gs296Good2.6Lower heart attack risk than average12 February 2015 02:21:47
Gs295Good2.8Lower heart attack risk than average12 February 2015 02:20:31
Gs2413lighter green, brown or hazel eye color12 February 2015 01:14:11
... further results


You can create a new genoset by clicking that link and filling in the form. But you'll still need to populate the criteria syntax.