Have questions? Visit https://www.reddit.com/r/SNPedia
These are 67 SNPs that definitely relate to FTO
Here they are:
You are encouraged to leave these fields blank, but hit save below. A bot will fill in everything correctly usually within 24h. If you're in a hurry, please see Template:Gene for a description of the fields.
Here you can edit the Free text: of the page
* 2015 research suggests [[rs1421085]] may be the causal variant [http://www.plengegen.com/blog/arid5b-fto-irx3irx5-regulatory-axis-drug-discovery-obesity-nejm/ blog summary]
* Within the [[FTO]] gene, [[rs9930506]] showed the strongest association with BMI (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were 1.3 BMI units heavier than homozygotes for the common "A" allele. More than 30 additional SNPs in or near the FTO gene were also studied, but they are co-inherited most of the time with the [[rs9930506]] SNP and therefore are unlikely to represent independent risk factors. These co-inherited SNPs include [[rs1421085]], [[rs9937053]], [[rs8043757]], [[rs3751812]], [[rs9923233]], [[rs9932754]], and [[rs9922619]]. [PMID 17658951]
* Note: The three [[FTO]] SNPs, [[rs1421085]], [[rs17817449]], and [[rs9939609]], are in strong linkage disequilibrium (pairwise r<sup>2</sup>>0.97), and there are two primary haplotypes, C-G-A (42.0%; this is the haplotype representing obesity risk) and T-T-T (55.5%).
* Another report fingers [[rs1121980]] within the [[FTO]] gene as having the strongest association to early onset [[obesity]] compared to several other SNPs all in the same linkage block. [PMID 18159244]
The earlier study also had conclusions with regard to another gene:
* Within the [[PFKP]] gene, [[rs6602024]] showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele. They did not replicate association between [[rs6602024]] and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele. [PMID 17658951]
New articles about this include:
[[FTO]] aka "Fat Gene"[http://www.dailytimes.com.pk/default.asp?page=2007%5C04%5C16%5Cstory_16-4-2007_pg6_14].
[http://www.alzforum.org/new/detail.asp?id=1567] the FTO SNP [[rs9939609]] is associated with changes in BMI and obesity in children by the age of 7 which persists into the pre-pubertal period and beyond.
[https://23andme.https.internapcdn.net/res/pdf/5-N8XiOLkGIgydwX_SS-IQ_23-08_Genetic_Associations_With_Traits.pdf “Genetic associations with traits in 23andMe customers.”] 23andMe White Paper.
This is a minor edit
Watch this page