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Cyclophosphamide

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Cyclophosphamide, the generic name for a drug often sold under the trade name Cytoxan, is a widely used chemotherapy drug. It is often used in combination with other drugs such as adriamycin and 5-fluorouracil. These combinations are often used in the treatment of breast cancer, but they often also cause adverse drug reactions (ADRs) including vomiting and neutropenia.(see also Wikipedia)

Cyclophosphamide is actually a prodrug that must be metabolically activated to become effective. Metabolic enzymes involved are encoded by a variety of genes including GSH, GSTP1, ALDH1A, ABCC2, and ABCC4, as well as various cytochrome p450 genes such as CYP2B6 and CYP2C9. SNPs in these genes may therefore alter both the efficacy and side-effect profile of this drug.

SNPs reported to do so include: